Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants
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102 citations
102 citations
Cites background from "Antitumor Activity of the MEK Inhib..."
...It demonstrated anti-tumor effects in vitro in melanoma cell lines and in vivo in patients-derived xenograft models [202]....
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35 citations
32 citations
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References
31,015 citations
"Antitumor Activity of the MEK Inhib..." refers methods in this paper
...Unsupervised hierarchical clustering was performed on these profiles and functional analysis of genes was performed using NIH DAVID (33)....
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...Functional analysis of these genes by NIH DAVID (33) revealed that the upregulated genes in the resistant samples were enriched with cell adhesion molecules (P 1⁄4 8....
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...Functional analysis of these genes by NIH DAVID (33) revealed that the upregulated genes in the resistant samples were enriched with cell adhesion molecules (P ¼ 8.7 10-5, FDR ¼ 0.009) and axon guidance (P ¼ 0.009, FDR ¼ 0.09), whereas downregulated genes were involved in homologous recombination (P ¼ 0.002, FDR ¼ 0.02) and systemic lupus erythematosus (P ¼ 0.01, FDR ¼ 0.1), according to KEGG pathway definitions (35)....
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10,630 citations
9,785 citations
"Antitumor Activity of the MEK Inhib..." refers background in this paper
...In many malignancies, including melanoma, the MAPK pathway has been shown to be upregulated, either through overexpression of extracellular growth factor ligands or by constitutive activation through mutations in RAS or RAF (2, 3, 6, 7)....
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...Activating mutations in BRAF have been found in approximately 60% of primary melanoma tumors (6, 9)....
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9,019 citations
"Antitumor Activity of the MEK Inhib..." refers methods in this paper
...Cell proliferation assays The effects of TAK-733 on cell proliferation were determined using the sulforhodamine B (SRB) method (31)....
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6,773 citations