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Antitumor Effects of Interferon Preparations In Mice
Ion Gresser,Chantal Bourali +1 more
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This article is published in Journal of the National Cancer Institute.The article was published on 1970-08-01. It has received 143 citations till now. The article focuses on the topics: Interferon.read more
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Cytokines in clinical cancer immunotherapy
Pedro Berraondo,Miguel F. Sanmamed,Maria C. Ochoa,Iñaki Etxeberria,Maria Angela Aznar,Jose Luis Perez-Gracia,Maria E. Rodriguez-Ruiz,Mariano Ponz-Sarvise,Eduardo Castanon,Ignacio Melero +9 more
TL;DR: The novel trends in the cytokine immunotherapy field that are yielding therapeutic agents for clinical trials are provided, including known molecules with novel mechanisms of action, new targets, and fusion proteins that increase half-life and target cytokine activity to the tumour microenvironment or to the desired effector immune cells.
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Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review.
Scott Wadler,Edward L. Schwartz +1 more
TL;DR: Preliminary data suggest that some combinations of interferon with conventional chemotherapeutic agents are not merely additive but rather that IFN may biochemically modulate the cellular uptake or metabolism of the cytotoxic agent resulting in synergistic antineoplastic activity.
Journal ArticleDOI
Mechanism of the antitumour effect of interferon in mice.
TL;DR: Infection of mouse interferon preparations inhibits the growth of several murine transplantable tumours and increases the survival of tumour inoculated mice, and enhances in some manner the capacity of the host to reject the transplanted tumour.
Journal ArticleDOI
Innate immune signaling and regulation in cancer immunotherapy
TL;DR: The successful development of effective innate immune activators should expand the fraction of patients that can respond to immunotherapies, such as with checkpoint blockade antibodies, and new strategies for triggering innate immune activation and Batf3 DC recruitment are being developed.