AP-1 as a regulator of cell life and death
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...sentative redox-sensitive transcription factor [161], which is involved in cell transformation and proliferation [139,162]....
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...In addition, ROS induce both the activation and synthesis of AP-1, a regulator of cell growth, proliferation, and apoptosis [138,139], and transcription factors such as STAT3, HIF-1α, and p53 [118,140,141]....
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3,647 citations
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...Activation of AP-1 binding may lead to the 4-HNEinduced increase in GSH content [239]....
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...AP-1 transcription factors control cell proliferation, survival, and death....
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...Involvement of AP-1 transcription factor in 4-HNEinduced cell signaling has been demonstrated by several studies which showed an AP-1 upregulation by 4-HNE [240– 243]....
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...Growth factors, cytokines, cellular stress, and many other stimuli activate AP-1 [244, 245]....
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...Thus, it is not a surprise that 4-HNE is nowadays considered as major bioactive marker of lipid peroxidation and a signaling molecule involved in regulation of several transcription factors sensible to stress such as nuclear factor erythroid 2-related factor 2 (Nrf2), activating protein-1 (AP-1), NF𝜅B, and peroxisome-proliferator-activated receptors (PPAR), in cell proliferation and/or differentiation, cell survival, autophagy, senescence, apoptosis, and necrosis (see below 4- HNE as signaling molecule)....
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3,404 citations
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...The dimer partner composition of AP-1 determines differential DNA binding-site specificity and as a result regulates the expression of a distinct subset of genes (Shaulian and Karin, 2002; van Dam and Castellazzi, 2001)....
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"AP-1 as a regulator of cell life an..." refers background in this paper
...p21-induced cycle arrest in G(1) protects cells from apoptosis...
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