Book ChapterDOI
Application of Microbial Toxins for Cancer Therapy
Rama Shanker Verma,Sirisha Potala,Mrudula Mathew,Swati Choudhary +3 more
- pp 647-662
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TLDR
Continuous efforts are being made to improve the specificity and efficacy of immunotoxins, to reduce size effects of the drugs, reduce immunogenicity and to improve better pharmacokinetics for drugs delivery.Abstract:
The principle of selective targeting of immunotoxins lies on the basis that cancer cells usually have few or specific growth factors/receptors/antigens highly over expressed on their surface. Ligands corresponding to these molecules are conjugated to modified toxins (modified to loss its native function) isolated form variety of bacterial populations. Normal cells either do not express these molecules or express at relatively low number leading to no or minimal adverse effects. The basic mechanism of action of these immunotoxins depends on the toxins employed. In this regard continuous efforts are being made to (i) Identity molecules exclusively expressed in cancer cells, (ii) to improve the specificity and efficacy (iii) reduce size effects of the drugs, (iv) Reduce immunogenicity and (v) to improve better pharmacokinetics for drugs delivery.read more
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Journal ArticleDOI
In Silico Analyses of Staphylococcal Enterotoxin B as a DNA Vaccine for Cancer Therapy
TL;DR: Assessment of the immunoreactivity of a SEB-coding DNA construct that serves as a DNA vaccine for breast cancer therapy revealed that apparently the construct could be efficiently expressed in mouse model, and could act as an amenable adjuvant in cancer immunotherapy.
References
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Journal Article
Les lymphocytes T‐CD8 : rôle dans l‘immunosurveillance et l‘immunothérapie antitumorale
Fabrice Benchetrit,Agnès Gazagne,Olivier Adotevi,Nacilla Haicheur,Brigitte Godard,Cécile Badoual,Wolf H. Fridman,Eric Tartour +7 more
TL;DR: In this paper, le role of lymphocytes T-CD8 antitumoraux in the control of the proliferation of tumeurs is discussed. But, the authors focus on the role of the lymphocyte T−CD8 cytotoxiques intratumoraux.
Journal ArticleDOI
Receptor upregulation enhances cell surface receptor targeted therapies.
TL;DR: It is reported that arginine butyrate increases the expression of the subunit of the IL2R on leukemia cells and that this leads to increased sensitivity to denileukin diftitox, and upregulation of receptors on malignant cells is an attractive strategy.
Journal ArticleDOI
Immunotoxin therapy for primary malignant brain tumors
Ki Uk Kim,Daniel A. Vallera,Hsiao Tzu Ni,Kwan H. Cho,Stephen R. Spellman,Walter C. Low,Walter A. Hall +6 more
TL;DR: Recombinant diphtheria toxin–murine interleukin-4 conjugate (DT 390 –mIL4) was developed and its cytotoxic efficacy against murine glioblastoma and neuroblastoma cell lines was examined, and the combined effect with irradiation was tested.