Application of nanotechnology in cancers prevention, early detection and treatment.
01 Jul 2014-Journal of Cancer Research and Therapeutics (J Cancer Res Ther)-Vol. 10, Iss: 3, pp 479-486
TL;DR: An overview of causes of cancer and the application of nanotechnology in cancer prevention, detection and treatment is provided.
Abstract: Use of nanotechnology in medical science is a rapidly developing area. New opportunities of diagnosis, imaging and therapy have developed due to recent rapid advancement by nanotechnology. The most common areas to be affected are diagnostic, imaging and targeted drug delivery in gastroenterology, oncology, cardiovascular medicine, obstetrics and gynecology. Mass screening with inexpensive imaging might be possible in the near future with the help of nanotechnology. This review paper provides an overview of causes of cancer and the application of nanotechnology in cancer prevention, detection and treatment.
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TL;DR: The state-of-art of nanostructured materials functionalized with metallodrugs as anticancer agents is described in this review, and the functionalization of several classes of metal complexes including platinum and non-platinum compounds is also addressed.
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TL;DR: This review highlights and discusses the main parameters affecting the outcome of preclinical MHT, aiming to provide adequate assistance in the design of new, more efficient MHT studies.
Abstract: Magnetic hyperthermia (MHT) is being investigated as a cancer treatment since the 1950s. Recent advancements in the field of nanotechnology have resulted in a notable increase in the number of MHT studies. Most of these studies explore MHT as a stand-alone treatment or as an adjuvant therapy in a preclinical context. However, despite all the scientific effort, only a minority of the MHT-devoted nanomaterials and approaches made it to clinical context. The outcome of an MHT experiment is largely influenced by a number of variables that should be considered when setting up new MHT studies. This review highlights and discusses the main parameters affecting the outcome of preclinical MHT, aiming to provide adequate assistance in the design of new, more efficient MHT studies.
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TL;DR: Antibacterial and anticancer applications and cytotoxicity of NBT-NPs are reviewed and the influences of optimum composition, size, surface structure, versatile chemistry and synergism are studied.
Abstract: Noble bimetallic and trimetallic nanoparticles (NBT-NPs) have superior biomedical applications as compared to their monometallic counterparts. The performance of these nanomaterials depends on thei...
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TL;DR: Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG–OAm functionalization, and PEG- and P EG–O am-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue.
Abstract: In this study, we investigated the effect of (ethylene glycol) (PEG) and PEG-oleylamine (OAm) functionalization on the skin permeation property of gold nanoparticles (GNS) in vivo. Chemisorption of polymers onto GNS was verified by a red shift in the ultraviolet-visible spectrum as well as by a change in the nanoparticle surface charge. The physicochemical properties of pristine and functionalized nanoparticles were analyzed by ultraviolet-visible spectroscopy, zeta potential analyzer, and transmission electron microscopy. Transmission electron microscopy revealed that the interparticle distance between nanoparticles increased after GNS functionalization. Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG-OAm functionalization. Moreover, PEG- and PEG-OAm-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. These findings demonstrate the potential of PEG- and PEG-OAm-functionalized GNS in serving a multitude of applications in transdermal pharmaceuticals.
32 citations
Cites background from "Application of nanotechnology in ca..."
...Introduction The use of nanotechnology in the form of nanomedicine for prevention, diagnosis, and treatment of diseases, including cancer, is one branch of this fast developing field.(1) Breakthroughs in particle size control and nanoparticle modification have created the possibility of designing nanoparticles that hold enormous potentials...
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TL;DR: The therapeutic applications of different nano-materials with a major focus on their applications for the treatment of cancer are discussed and the toxicity of conventional nanostructures is mentioned.
Abstract: Most of mortality worldwide occurs because of cancer diseases. Nanostructures are the new compounds that have become one of the most important technologies for using in different fields over the past two years especially in medicine. In between, nanotechnology has the potential to cancer detection and therapy. This study is a review of prospects in applications of nano-materials for cancer detection and treatment. We have summarized the nano-materials (metal nanospheres, nanorods, nanoshells and nanotubes) in medical applications targeting cancer. We also discuss advances in established nanoparticle technologies such as liposomes, polymer micelles, and functionalization about tumor targeting, controlled release and drug delivery. This paper will discuss the therapeutic applications of different nano-materials with a major focus on their applications for the treatment of cancer. Briefly, the toxicity of conventional nanostructures was also mentioned in this paper.
16 citations
Cites background from "Application of nanotechnology in ca..."
...Zinc oxide and titanium dioxide nanoparticles are used for this purpose [51, 52]....
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...For example, computer chips, nanowires which are connected to very sensitive ampere meter with high affinity for binding to specific biomolecules and nano-arrays of atomic force microscope which have been equipped with specific antibodies for target molecule are only part of these studies [52]....
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