Journal ArticleDOI
Application of nanotechnology in treatment of leishmaniasis: A Review.
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TLDR
This study attempts to present a comprehensive overview of different approaches of nanotechnology in treatment of leishmaniasis as well as new drug delivery devices transport antileishmanial drug to the target cell specifically with minimizing the toxic effects to normal cells.About:
This article is published in Acta Tropica.The article was published on 2017-08-01. It has received 101 citations till now. The article focuses on the topics: Leishmaniasis & Visceral leishmaniasis.read more
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Green Synthesis of Zinc Oxide (ZnO) Nanoparticles Using Aqueous Fruit Extracts of Myristica fragrans: Their Characterizations and Biological and Environmental Applications.
Shah Faisal,Hasnain Jan,Hasnain Jan,Sajjad Ali Shah,Sumaira Shah,Adnan Khan,Muhammad Akbar,Muhammad Rizwan,Faheem Jan,Wajidullah,Noreen Akhtar,Aishma Khattak,Suliman Syed +12 more
TL;DR: In this paper, bio-augmented zinc oxide nanoparticles (ZnO-NPs) were prepared from aqueous fruit extracts of Myristica fragrans.
Journal ArticleDOI
Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects.
TL;DR: In this article, a review summarizes the recent progress in the biogenesis of plant-based SeNPs by using various plant species and the role of secondary metabolites on their biocompatible functioning.
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Leishmaniasis diagnosis: an update on the use of parasitological, immunological and molecular methods.
TL;DR: Among the molecular techniques, polymerase chain reaction is the most commonly used technique that is successfully implied for diagnosis and various methods utilized with their advantages and limitations are provided.
Journal ArticleDOI
Silver and gold nanoparticles from tannic acid: synthesis, characterization and evaluation of antileishmanial and cytotoxic activities.
Lourdes C. da S. Lopes,Lucas Moreira Brito,Thayllan T Bezerra,Kleyton N Gomes,Fernando Aécio de Amorim Carvalho,Mariana Helena Chaves,Welter Cantanhêde +6 more
TL;DR: CC50 value for AgNPs-TA suggested that TA attenuates nanosilver toxicity comparatively to its precursor (Ag+), which can contribute to the development of new, green, and fast produced drugs aiming at leishmaniasis treatment.
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Bovine serum albumin nanoparticles containing amphotericin B were effective in treating murine cutaneous leishmaniasis and reduced the drug toxicity.
TL;DR: The antileishmanial efficacy and the reduced toxicity become BSA nanoparticles containing AmB a potential candidate for treating cutaneous leishmaniasis.
References
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Journal ArticleDOI
The importance of selenium to human health
TL;DR: Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
The importance of selenium to human health.
TL;DR: The essential trace mineral, selenium, is of fundamental importance to human health as mentioned in this paper, and it is needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS.
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Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
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Principles of early drug discovery
TL;DR: This review will look at key preclinical stages of the drug discovery process, from initial target identification and validation, through assay development, high throughput screening, hit identification, lead optimization and finally the selection of a candidate molecule for clinical development.
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Advances in leishmaniasis.
TL;DR: Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions), and disseminated infection (cutaneous, mucosal, or visceral).