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Application of support vector machines in viral biology

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TLDR
This chapter provides lucid and easy to understand details of SVM algorithms along with applications in virology, one such robust tool based rigorously on statistical learning theory.
Abstract
Novel experimental and sequencing techniques have led to an exponential explosion and spiraling of data in viral genomics. To analyse such data, rapidly gain information, and transform this information to knowledge, interdisciplinary approaches involving several different types of expertise are necessary. Machine learning has been in the forefront of providing models with increasing accuracy due to development of newer paradigms with strong fundamental bases. Support Vector Machines (SVM) is one such robust tool, based rigorously on statistical learning theory. SVM provides very high quality and robust solutions to classification and regression problems. Several studies in virology employ high performance tools including SVM for identification of potentially important gene and protein functions. This is mainly due to the highly beneficial aspects of SVM. In this chapter we briefly provide lucid and easy to understand details of SVM algorithms along with applications in virology.

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Posted ContentDOI

A machine learning based analysis to probe the relationship between odorant structure and olfactory behaviour in C. elegans

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References
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Book ChapterDOI

T-cell epitope prediction methods: an overview.

TL;DR: This chapter aims to introduce the reader to the principle(s) underlying some of the methods/algorithms developed to predict T-cell epitopes as well as procedural and practical aspects of using the same.
Journal ArticleDOI

Prediction of HIV-1 and HIV-2 proteins by using Chou’s pseudo amino acid compositions and different classifiers

Juan Mei, +1 more
- 05 Feb 2018 - 
TL;DR: The results of the jackknife test indicated that the highest prediction accuracy and CC values were obtained by the SVM and MP were 0.9909 and 0.9763, respectively, indicating that the classifiers presented in this study were suitable for predicting two groups of HIV proteins.
Journal ArticleDOI

AVCpred: an integrated web server for prediction and design of antiviral compounds.

TL;DR: QSAR‐based models for predicting antiviral compounds (AVCs) against deadly viruses like human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), human herpesvirus (HHV) and 26 others using publicly available experimental data from the ChEMBL bioactivity database are developed.
Journal ArticleDOI

A quantitative quasispecies theory-based model of virus escape mutation under immune selection

TL;DR: The results demonstrate that, by explicitly representing epitope mutations and thus providing a genotype–phenotype map, the quasispecies theory can form the basis of a detailed sequence-specific model of real-world viral pathogens evolving under immune selection.
Journal ArticleDOI

Predicting protein–protein interactions between human and hepatitis C virus via an ensemble learning method

TL;DR: An ensemble learning method to predict PPIs between human and HCV proteins using four well-established diverse learners as base classifiers and reveals that the method is suitable for performing PPI prediction in a host-pathogen context.
Related Papers (5)
Trending Questions (1)
What are the potential applications of machine learning in virology?

Machine learning, specifically Support Vector Machines (SVM), is used in virology for tasks such as epitope prediction, virus-host interaction detection, and influenza host prediction.