Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging
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...Complexes of manganese (Mn) have been proposed as Gd-free alternatives to GBCAs and have received increasing attention.(14) The Mn ion is a strong T1-relaxation agent and is also an endogenously present nutritional element that can be eliminated by the human body....
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...G adolinium (Gd)-based contrast agents (GBCAs) for magnetic resonance imaging (MRI) play an integral role in modern radiology, but safety concerns over long-term Gd retention and delayed-onset toxicity are driving research efforts to identify Gd-free alternatives for contrast-enhanced MRI.(13,14) Gadolinium is associated with nephrogenic systemic fibrosis, a rare but debilitating condition observed in renally impaired patients who have received contrast-enhanced MRI examinations....
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...Group 3 comprised 2 normal Wistar rats (1 M/1 F) receiving 0.01 mmol/ kg [52Mn]Mn-DPDP who underwent dynamic PET-MRI....
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...Group 2 comprised six 5/6 nephrectomy rats (3 M/3 F) receiving 0.2 mmol/kg [52Mn]Mn-PyC3A who underwent dynamic PET-MRI....
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...Group 1 comprised 6 normal rats (3 M/3 F) receiving 0.2 mmol/kg [52Mn]Mn-PyC3A who underwent dynamic PET-MRI....
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