Applications of computational algorithm tools to identify functional SNPs
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Cites background from "Applications of computational algor..."
...However, there are accumulating evidences that mutations in the splice, donor and acceptor sites or enhancer, intron and promoter elements may be important in genetic expression and regulation [31]....
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Cites background from "Applications of computational algor..."
...Although wetlab-based approaches used to identify disease-associated SNPs from a large number of neutral SNPs remain crucial evidence for the functional role of SNPs [8], numerous disease associations published could not be confirmed by subsequent independent studies [6, 9]....
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45 citations
Cites methods from "Applications of computational algor..."
...Two integrated bioinformatics tools, “F-SNP” [18] (http://compbio.cs.queensu.ca/F-SNP/) and “FAST SNP” [19] (http://fastsnp.ibms.sinica.edu.tw/pages/input_CandidateGeneSearch.jsp), were applied to predict the potential function of SNPs....
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...ca/F-SNP/) and “FAST SNP” [19] (http://fastsnp....
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...In addition to the functional SNP TERT-rs2853669, two other candidate SNPs, TERT-rs2736108 and CLPTM1L-rs31490, were selected utilizing the union of two tools by bioinformatics approaches [18,19]....
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References
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"Applications of computational algor..." refers background or methods in this paper
...Using the human transcription factor TP53 as a test case The human gene TP53 (tumor suppressor gene) is mutated in more than 50% of human cancers and p53 dysfunction is caused through a direct mutation within the DNA binding domain of the gene (Vogelstein et al. 2000)....
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...The human gene TP53 (tumor suppressor gene) is mutated in more than 50% of human cancers and p53 dysfunction is caused through a direct mutation within the DNA binding domain of the gene (Vogelstein et al. 2000)....
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6,449 citations
"Applications of computational algor..." refers methods in this paper
...SNP dataset from dbSNP SNP dataset for TP53 gene investigated in this work was retrieved from dbSNP (Sherry et al. 2001) http://www.ncbi. nlm.nih.gov/SNP/ for our computational analysis....
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...SNP dataset for TP53 gene investigated in this work was retrieved from dbSNP (Sherry et al. 2001) http://www....
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5,318 citations
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