Book•
Applications of Solid Phase Microextraction
04 Jun 1999-
TL;DR: The use of SPME to measure free concentrations and phospholipid/water and protein/water partition coefficients of organic compounds has been extensively used in the literature as discussed by the authors.
Abstract: Foreword Contents Contributors Glossary Calibration and quantitation by SPME Quantitative aspects of SPME Quantitation by SPME before reaching a partition equilibrium Coatings and interfaces SPME coupled to capillary electrophoresis Selectivity in SPME Properties of commericial SPME coatings Sol-gel technology for thermally stable coatings in SPME Solid versusliquids coatings Physiochemical applications Application of SPME to study sorption phenomena on dissolved humic organic matter The use of SPME to measure free concentrations and phospholipid/water and protein/water partition coefficients Estimation of hydrophobicity of organic compounds Environmental applications Air sampling with SPME The application of sPME in water analysis The application of SPME to pestivide residue analysis Inter-laboratory validation of SPME for the quantitative analysis of aqueous samples SPME for the determination of organochlorine pestivides in natural waters Determination of sulfur-containing compounds in wastewater Analysis of creosote and oil in aqueous contaminations by SPME Direct analysis of solids using sPME Analysis of solid samples by hot water extraction -SPME Field analysis by SPME Organometallic speciation by combining aqueous phase derivatization with SPME-GC-FPD-MS Metal speciation by SPME-CGC-ICPMS The application of SPME-LC-MS to the determination of contaminants in complex environmental matrices SPME-HPLC of environmental pollutants Analysis of industrial pollutants in environmental samples Food, flavour, fragrance and pheromone applications Analysis of food and plant volatiles Application of SPME to measure volatile metabolites produced by staphylococcus carnosus and staphylococcus xylosus Application of SPME methods for the determination of volatile wine aroma compounds in view of the varietal characterization Analysis of vodkas and white rums by SPMS-GC-MS Analysis of food volatiles using SPME Analysis of volatile contaminants in foods Determination of pesticides in foods by automated SPMS-GC-MS SPME in the study of chemical communication in social wasps Pharmaceutical, clinical and forensic applications Propyl chloroformate derivatisation and SPME-GC for screening Of amines in urine Isolation of drugs and poisons in biological fluids by SPME On-fiber derivatization for analysis of steroids by SPME and GC-MS SPME-Quadrupole ion trap mass spectrometry for the determination of drugs of abuse in biological matrices Analysis of drugs in biological fluids using SPME SPME-Microcolumm LC: Application to toxicological drug analysis Optimization of drug analysis by SPME Applications of SPME for the biomonitoring of human exposure to toxic substances Applications of SPME in criminal investigations Reaction monitoring SPME-GC-MS detection analysis of maillard reaction products SPME investigation of intermediates produced during biodegradation of contaminated materials Related techniques Infrared spectroscopic detection for SPME SPME in Near-IR Fiber-optic Evanescent Field Absorption Spectroscopy: A Method for Rapid, Remote In situ Monitoring of Nonpolar Organic Compounds in Water Author Index
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TL;DR: The SPME technique can be used routinely in combination with gas Chromatography (GC), GC-mass spectrometry (GC-MS), high-performance liquid chromatography (HPLC) or LC-MS, and can improve the detection limits.
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TL;DR: Special attention will be devoted to the use of tandem-mass spectrometric (MS/MS) techniques for the characterization of several important sub-classes of flavonoids, and to the potential of combined diode-array UV (DAD UV), tandem-MS and nuclear magnetic resonance (NMR) detection for unambiguous identification.
627 citations
TL;DR: The SPME technique is ideally suited for MS applications, combining a simple and efficient sample preparation with versatile and sensitive detection, and its applications in combination with MS.
Abstract: Sample preparation is an essential step in analysis, greatly influencing the reliability and accuracy of resulted the time and cost of analysis. Solid-Phase Microextraction (SPME) is a very simple and efficient, solventless sample preparation method, invented by Pawliszyn in 1989. SPME has been widely used in different fields of analytical chemistry since its first applications to environmental and food analysis and is ideally suited for coupling with mass spectrometry (MS). All steps of the conventional liquid-liquid extraction (LLE) such as extraction, concentration, (derivatization) and transfer to the chromatograph are integrated into one step and one device, considerably simplifying the sample preparation procedure. It uses a fused-silica fibre that is coated on the outside with an appropriate stationary phase. The analytes in the sample are directly extracted to the fibre coating. The SPME technique can be routinely used in combination with gas chromatography, high-performance liquid chromatography and capillary electrophoresis and places no restriction on MS. SPME reduces the time necessary for sample preparation, decreases purchase and disposal costs of solvents and can improve detection limits. The SPME technique is ideally suited for MS applications, combining a simple and efficient sample preparation with versatile and sensitive detection. This review summarizes analytical characteristics and variants of the SPME technique and its applications in combination with MS.
550 citations
TL;DR: The principles of stir bar sorptive extraction are described and an overview of SBSE applications is given, as illustrated by several successful applications in trace analysis in environmental, food and biomedical fields.
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TL;DR: This review will attempt to provide an overview as well as a theoretical and practical understanding of the use of microextraction technologies for drug analysis, with particular emphasis on the effect various sample matrices have on extraction characteristics.
423 citations