Journal ArticleDOI
Aqueous fenugreek seed extract ameliorates adriamycin-induced cytotoxicity and testicular alterations in albino rats.
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TLDR
It is indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.Abstract:
The present work studied the effect of fenugreek seed extracts on cytotoxicity and testicular damage induced by adriamycin (ADR) in albino rats. Administrating animals with ADR caused significant increase in the percentage of chromosomal aberrations, decreased the mitotic index, and induced DNA damage in bone marrow. Testes of ADR-treated rats showed many histopathological alterations and the number of sperm head abnormalities increased. Moreover, the concentration of malondialdehyde (MDA) increased and the activity of catalase (CAT) and superoxide dismutase (SOD) decreased in the testis. Treating animals with ADR and aqueous seed extracts of fenugreek led to an improvement in the cytogenetic effect and testicular alterations induced by ADR. Lipid peroxidation was reduced and the activities of CAT and SOD were increased. In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.read more
Citations
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Journal ArticleDOI
Fenugreek seed powder mitigates cadmium-induced testicular damage and hepatotoxicity in male rats.
TL;DR: The results of the present work indicated that fenugreek seed powder (FSP) may represent a promising medicinal herb to protect hepatic and testicular tissues from the detrimental effects of cadmium.
Journal ArticleDOI
Fenugreek seed extract attenuates cisplatin-induced testicular damage in Wistar rats.
TL;DR: It is concluded that FSE reduces CIS‐induced reproductive toxicity in rats by the suppression of testicular oxidative stress, apoptosis and inflammations.
Journal ArticleDOI
Anticancer potential of Trigonella foenum graecum: Cellular and molecular targets.
TL;DR: In this paper, a review of the potential of fenugreek in cancer treatment and prevention is presented, where the authors discuss the chemical constituents and bioactive compounds of Fenugreek, effects on oxidative stress and inflammation, proliferation, apoptosis, and invasion, toxicity, and future directions in cancer drug development.
Journal ArticleDOI
Gingerol Synergizes the Cytotoxic Effects of Doxorubicin against Liver Cancer Cells and Protects from Its Vascular Toxicity.
Fahad A. Al-Abbasi,Eman A. Al-Ghamdi,Mohammed A. Baghdadi,Abdulmohsin J. Alamoudi,Ali M. El-Halawany,Hany M. El-Bassossy,Hany M. El-Bassossy,Ali H Aseeri,Ahmed M. Al-Abd +8 more
TL;DR: Gingerol protected from DOX-induced vascular damage, apparently not through a ROS scavenging mechanism, and synergized the cytotoxic effects of DOX against liver cancer cells without influencing the cellular pharmacokinetics.
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The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology
TL;DR: Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility, and couples planning pregnancy should be discouraged from the consumption of these herbs.
References
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques
Salah M. Aljanabi,Iciar Martinez +1 more
TL;DR: The quantity and the quality of the DNA extracted by this method is high enough to perform hundreds of PCR-based reactions and also to be used in other DNA manipulation techniques such as restriction digestion, Southern blot and cloning.
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Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells.
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Spermatogenesis After Cancer Treatment: Damage and Recovery
Sacha J Howell,Stephen M Shalet +1 more
TL;DR: The vast majority of men receiving procarbazine-containing regimens for the treatment of lymphomas are rendered permanently infertile, whereas treatment with doxorubicin hydrochloride (Adriamycin), bleomycin, vinblastine, and dacarbazine appears to have a significant advantage, with a return to normal fertility in the vastmajority of patients.
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Free radical formation by antitumor quinones
TL;DR: The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated and it is suggested that cardiotoxicity and skin toxicity may also be related to oxygen radical formation.