Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.
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...Data for this figure was extracted from the following sources: SOD1 [21], SOD2 [26], and SOD3 [32]....
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...The SOD1 gene has been localized to chromosome 21 (region 21q22) in humans [21], chromosome 1 (1q123 14) in bovine species [39], and chromosome 16 (region 16B43 ter) in the mouse [40]....
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...The genomic sequence for SOD1 has been identified in the rat [18,19], mouse [20], and human [21]....
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...Second, the amino terminal residues [96–193] contain active site, showing about 50% homology to SOD1....
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...Three classes of SOD have evolved in various organisms possessing different catalytic metal ions: Cu/Zn SODs, Mn SOD/Fe SODs, and Ni SODs (Table S1; Levanon et al., 1985; Campbell et al., 1986; Chang et al., 1988; Wan et al., 1994; Jones et al., 1995; Strålin et al., 1995; Duttaroy et al., 1997; Folz et al., 1997; Antonyuk et al., 2009; Jung et al., 2011; Blackney et al., 2014)....
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