Journal ArticleDOI
Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
Reads0
Chats0
TLDR
It is suggested that arecoline inhibits pineal–testis function in experimentally induced hypothyroid rats.Abstract:
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum N-acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.read more
Citations
More filters
Journal ArticleDOI
DARK Classics in Chemical Neuroscience: Arecoline.
Andrey D. Volgin,Alim Bashirzade,Tamara G. Amstislavskaya,Oleg A. Yakovlev,Konstantin A. Demin,Ying-Jui Ho,Dongmei Wang,Vadim A. Shevyrin,Dongni Yan,Zhichong Tang,Jingtao Wang,Mengyao Wang,Erik T. Alpyshov,Nazar Serikuly,Edina A. Wappler-Guzzetta,Anton M. Lakstygal,Allan V. Kalueff +16 more
TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.
Dissertation
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin
Journal ArticleDOI
Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha-lipoic acid
Amal Al-Shahat Ibrahim,N A Mohammed,K A Eid,Mosleh M. Abomughaid,Aaser M. Abdelazim,Adel Mohamed Aboregela +5 more
TL;DR: AlA supplementation ameliorated the toxicity induced by hypothyroidism as illustrated by enhanced reproductive organ weights, testosterone, LH, and FSH levels, testicular steroidogenesis, and oxidative stress parameters.
Journal ArticleDOI
Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data.
TL;DR: New insights into the underlying pathogenesis of RA and OA are suggested, which may improve the diagnosis and treatment of these intractable chronic diseases.
Journal ArticleDOI
ENHANCED p53-DEPENDENT GROWTH INHIBITION OF HUMAN GLIOBLASTOMA CELLS BY COMBINATORIAL TREATMENT OF TEMOZOLOMIDE AND NOVEL PURIFIED NATURAL CARBOHYDRATE OF PLEUROTUS FLORIDA
Priyankar Maji,Ranodeep Chatterjee,Shibani Basu,Biswa Choudhury,Urmi Chatterji,Jhuma Ganguly +5 more
TL;DR: It confirms that Fr-II synergizes with TMZ to significantly intensify its anti-proliferative properties, thereby emerging as an effective element for combinatorial treatment of glioblastoma.
References
More filters
Journal ArticleDOI
Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function.
Pulak R. Manna,Jukka Kero,Manuel Tena-Sempere,Pirjo Pakarinen,Douglas M. Stocco,Ilpo Huhtaniemi +5 more
TL;DR: A dual response mechanism of T(3) on steroidogenesis and StAR expression, and on LH receptor (LHR) expression and binding in mLTC-1 cells is reported, which further characterize the thyroid-gonadal connection and provide insights into the mechanisms for a dual regulatory role of thyroid hormone in Leydig cell functions.
Journal ArticleDOI
Effect of intravaginal implants of melatonin on the onset of ovarian activity in adult and prepubertal ewes
R. Nowak,R. G. Rodway +1 more
TL;DR: The results demonstrate that continuous melatonin administration to adult and prepubertal ewes can mimic the effect of short days in terms of the reproductive response, and that the present and previous exposure to melatonin is critical in determining the response.
Journal ArticleDOI
A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones.
Jérome Gilleron,Marielle Nebout,L. Scarabelli,Francoise Senegas-Balas,S. Palmero,Dominique Segretain,G. Pointis +6 more
TL;DR: It is demonstrated that the inhibitory effect of T3 on Sertoli cell growth was associated with a time and dose‐dependent increase in the levels of Cx43, a constitutive protein of gap junctions, known to participate in the control of cell proliferation and the most predominant Cx in the testis.
Journal ArticleDOI
Effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia.
TL;DR: Betel chewing is associated with milder symptomatology and avoidance of more harmful recreational drugs, and initial results indicate that longitudinal research is merited.