Journal ArticleDOI
Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
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TLDR
It is suggested that arecoline inhibits pineal–testis function in experimentally induced hypothyroid rats.Abstract:
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum N-acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.read more
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Journal ArticleDOI
DARK Classics in Chemical Neuroscience: Arecoline.
Andrey D. Volgin,Alim Bashirzade,Tamara G. Amstislavskaya,Oleg A. Yakovlev,Konstantin A. Demin,Ying-Jui Ho,Dongmei Wang,Vadim A. Shevyrin,Dongni Yan,Zhichong Tang,Jingtao Wang,Mengyao Wang,Erik T. Alpyshov,Nazar Serikuly,Edina A. Wappler-Guzzetta,Anton M. Lakstygal,Allan V. Kalueff +16 more
TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.
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References
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Journal ArticleDOI
Effect of hypothyroidism on the testes in mature rats and treatment with levothyroxine and zinc.
TL;DR: After treatment, testicular histology and spermatogenesis gradually recovered in all groups with hypothyroidism, but maximum improvement was achieved in the levothyroxine+zinc sulphate replacement group, indicating a possible role of zinc in testicular function.
Journal ArticleDOI
Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil
Y. Yang,C. J. Gordon +1 more
TL;DR: The regulation of Tc at hypothermic levels over a wide range of Ta values and when rats were housed in a temperature gradient indicates that chronic PTU induces a state of regulated hypothermia.
Journal ArticleDOI
Ultrastructural interrelationship between the pineal gland and the testis in the male rat
TL;DR: Pinealectomy and orchidectomy caused hyperactivity in Leydig cells and pinealocytes, respectively, which suggests a mutual relationship between the pineal gland and testis in the rat.
Journal ArticleDOI
Effect of methimazole-induced hypothyroidism on adrenal and gonadal functions in male Japanese quail (Coturnix japonica).
Qiang Weng,Erina Saita,Erina Saita,Gen Watanabe,Gen Watanabe,Shinji Takahashi,Manila Sedqyar,Manila Sedqyar,Akira K. Suzuki,Shinji Taneda,Kazuyoshi Taya,Kazuyoshi Taya +11 more
TL;DR: The results clearly demonstrate that hypothyroidism caused both gonadal and adrenal disturbances in the adult male Japanese quail.
Journal ArticleDOI
Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice.
Romi Dasgupta,Urmi Chatterji,Tapas Chandra Nag,Santasri Chaudhuri-Sengupta,Debabrata Nag,B. R. Maiti +5 more
TL;DR: Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40 min) arecline treatment, and atropine prevents thyroid dysfunction induced by arecoline.