Journal ArticleDOI
Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
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TLDR
It is suggested that arecoline inhibits pineal–testis function in experimentally induced hypothyroid rats.Abstract:
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum N-acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.read more
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Journal ArticleDOI
DARK Classics in Chemical Neuroscience: Arecoline.
Andrey D. Volgin,Alim Bashirzade,Tamara G. Amstislavskaya,Oleg A. Yakovlev,Konstantin A. Demin,Ying-Jui Ho,Dongmei Wang,Vadim A. Shevyrin,Dongni Yan,Zhichong Tang,Jingtao Wang,Mengyao Wang,Erik T. Alpyshov,Nazar Serikuly,Edina A. Wappler-Guzzetta,Anton M. Lakstygal,Allan V. Kalueff +16 more
TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.
Dissertation
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin
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Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha-lipoic acid
Amal Al-Shahat Ibrahim,N A Mohammed,K A Eid,Mosleh M. Abomughaid,Aaser M. Abdelazim,Adel Mohamed Aboregela +5 more
TL;DR: AlA supplementation ameliorated the toxicity induced by hypothyroidism as illustrated by enhanced reproductive organ weights, testosterone, LH, and FSH levels, testicular steroidogenesis, and oxidative stress parameters.
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Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data.
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ENHANCED p53-DEPENDENT GROWTH INHIBITION OF HUMAN GLIOBLASTOMA CELLS BY COMBINATORIAL TREATMENT OF TEMOZOLOMIDE AND NOVEL PURIFIED NATURAL CARBOHYDRATE OF PLEUROTUS FLORIDA
Priyankar Maji,Ranodeep Chatterjee,Shibani Basu,Biswa Choudhury,Urmi Chatterji,Jhuma Ganguly +5 more
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References
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Journal ArticleDOI
Maternal transfer of melatonin alters the growth and sexual maturation of young Indian palm squirrel Funambulus pennanti.
K.S. Bishnupuri,Chandana Haldar +1 more
TL;DR: The results support the earlier concept and show for the first time that MEL can be transported from the mother to the young either prenatally through the placenta or postnatally via the milk in order to influence neonatal growth and sexual maturation.
Journal ArticleDOI
Melatonin stimulates thyroid-stimulating hormone accumulation in the thyrotropes of the rat pars tuberalis.
TL;DR: It is demonstrated that melatonin stimulates the accumulation of TSH in the rat PT-TSH cells via secretory granule formation and suggest thatmelatonin regulates TSH release from PT- TSH cells.
Journal ArticleDOI
Ultrastructural and hormonal changes in the pineal-testicular axis following arecoline administration in rats.
Indraneel Saha,Urmi Chatterji,Santasri Chaudhuri-Sengupta,Tapas Chandra Nag,Debabrata Nag,Samir Banerjee,B. R. Maiti +6 more
TL;DR: The findings suggest that arecoline inhibits pineal activity, but stimulates testicular function (testosterone level) and its target organs presumably via muscarinic cholinergic receptor in rats.
Dissertation
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin
Journal ArticleDOI
Influence of melatonin and serotonin on the number of rat pineal "synaptic" ribbons and spherules in vitro.
TL;DR: The results obtained indicate that the numbers of SR and SS are influenced by melatonin and serotonin and that the two structures are regulated by differential, but nevertheless biochemically closely related mechanisms.