Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Robert M. Weisbrod,Tina Shiang,Leona Al Sayah,Jessica L. Fry,Saumendra Bajpai,Cynthia A. Reinhart-King,Heinrich E. Lob,Lakshmi Santhanam,Gary F. Mitchell,Richard A. Cohen,Francesca Seta +10 more
Reads0
Chats0
TLDR
In a diet-induced model of obesity, arterial stiffness, measured in vivo, develops within 1 month of the initiation of the diet and precedes the development of hypertension by 5 months, supporting the hypothesis that arterial stiffening is a cause rather than a consequence of hypertension.Abstract:
Stiffening of conduit arteries is a risk factor for cardiovascular morbidity. Aortic wall stiffening increases pulsatile hemodynamic forces that are detrimental to the microcirculation in highly perfused organs, such as the heart, brain, and kidney. Arterial stiffness is associated with hypertension but presumed to be due to an adaptive response to increased hemodynamic load. In contrast, a recent clinical study found that stiffness precedes and may contribute to the development of hypertension although the mechanisms underlying hypertension are unknown. Here, we report that in a diet-induced model of obesity, arterial stiffness, measured in vivo, develops within 1 month of the initiation of the diet and precedes the development of hypertension by 5 months. Diet-induced obese mice recapitulate the metabolic syndrome and are characterized by inflammation in visceral fat and aorta. Normalization of the metabolic state by weight loss resulted in return of arterial stiffness and blood pressure to normal. Our findings support the hypothesis that arterial stiffness is a cause rather than a consequence of hypertension.read more
Citations
More filters
Journal ArticleDOI
Aging, arterial stiffness, and hypertension.
TL;DR: It is generally thought that hypertension is an aging disorder, and aging-related hypertension is characterized by a significant increase in systolic blood pressure with no change or even a …
Journal ArticleDOI
The pathophysiology of hypertension in patients with obesity
TL;DR: The pathophysiology of obesity-related hypertension is especially relevant to premenopausal women with obesity and type 2 diabetes mellitus who are at high risk of developing arterial stiffness and endothelial dysfunction.
Journal ArticleDOI
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
TL;DR: Therapeutic interventions that target tissue stiffening are discussed in the context of their limitations, preclinical drug development efforts, and clinical trials.
Journal ArticleDOI
Age-related vascular stiffening: causes and consequences.
TL;DR: The underlying causes of age-related vessel stiffening are discussed, focusing on age- related crosslinking of the ECM proteins as well as through increased matrix deposition, and very recent work that demonstrates endothelial cells are mechano-sensitive to arterial stiffening, where changes in stiffness can directly impact EC health is discussed.
Journal ArticleDOI
Arterial Stiffness and Hypertension: Chicken or Egg?
TL;DR: During the past 2 decades, measures of aortic stiffness have emerged as important risk factors for progression of blood pressure and incident cardiovascular disease and elevated CFPWV is associated with high risk for incident hypertension and cardiovascular disease.
References
More filters
Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association
Véronique L. Roger,Alan S. Go,Donald M. Lloyd-Jones,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Diane M. Makuc,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Claudia S. Moy,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Elsayed Z. Soliman,Paul D. Sorlie,Nona Sotoodehnia,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +36 more
TL;DR: The American Heart Association's 2020 Impact Goals for Cardiovascular Diseases and Disorders are revealed, with a focus on preventing, treating, and preventing heart disease and stroke.
Journal ArticleDOI
Arterial Stiffness and Cardiovascular Events The Framingham Heart Study
Gary F. Mitchell,Shih-Jen Hwang,Ramachandran S. Vasan,Martin G. Larson,Michael J. Pencina,Naomi M. Hamburg,Joseph A. Vita,Daniel Levy,Emelia J. Benjamin +8 more
TL;DR: Higher aortic stiffness assessed by PWV is associated with increased risk for a first cardiovascular event and improves risk prediction when added to standard risk factors and may represent a valuable biomarker of cardiovascular disease risk in the community.
Journal ArticleDOI
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience.
TL;DR: The overweight category is associated with increased relative and population attributable risk for hypertension and cardiovascular sequelae and interventions to reduce adiposity and avoid excess weight may have large effects on the development of risk factors and cardiovascular disease at an individual and population level.
Journal ArticleDOI
The Emerging Concept of Vascular Remodeling
Gary H. Gibbons,Victor J. Dzau +1 more
TL;DR: Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes -- cell growth, cell death, cell migration, and production or degradation of extracellular matrix -- and is dependent on a dynamic interaction between locally.
Related Papers (5)
Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects
Yoav Ben-Shlomo,Melissa Spears,Chris Boustred,Margaret T May,Simon G. Anderson,Emelia J. Benjamin,Pierre Boutouyrie,James D. Cameron,Chen Huan Chen,J. Kennedy Cruickshank,Shih-Jen Hwang,Edward G. Lakatta,Stéphane Laurent,João Maldonado,Gary F. Mitchell,Samer S. Najjar,Anne B. Newman,Mitsuru Ohishi,Bruno Pannier,Telmo Pereira,Ramachandran S. Vasan,Tomoki Shokawa,Kim Sutton-Tyrell,Francis Verbeke,Kang Ling Wang,David J. Webb,Tine W. Hansen,Sophia Zoungas,Carmel M. McEniery,John R. Cockcroft,Ian B. Wilkinson +30 more