Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration
About: This article is published in Journal of Chronic Diseases.The article was published on 1970-11-01. It has received 245 citations till now. The article focuses on the topics: Service (business).
Citations
More filters
TL;DR: Infection with H. pylori is strongly associated with an increased risk of gastric carcinoma, and the association was strong even for men in whom the diagnosis was made 10 or more years after the serum sample was obtained.
Abstract: Background. Helicobacter pylori are gram-negative spiral bacteria that are associated with chronic gastritis, a known precursor of gastric carcinoma. Persons at high risk for gastric carcinoma have been shown to have a high prevalence of H. pylori infection. Methods. We studied the relation of H. pylori infection and gastric carcinoma in a cohort of Japanese American men living in Hawaii. The 5908 men were enrolled and examined from 1967 to 1970. By 1989, 109 cases of pathologically confirmed gastric carcinoma had been identified. The stored serum of each patient with gastric carcinoma and of each matched control subject was tested for the presence of serum lgG antibody to H. pylori. Results. Ninety-four percent of the men with gastric carcinoma and 76 percent of the matched control subjects had a positive test for H. pylori antibodies, for an odds ratio of 6.0 (95 percent confidence interval, 2.1 to 17.3). As the level of antibody to H. pylori increased, there was a progressive increase in the r...
1,765 citations
Journal Article•
TL;DR: It is concluded that infection with a cagA-positive H. pylori strain in comparison with acagA -negative strain somewhat increases the risk for development of gastric cancer, especially intestinal type affecting the distal stomach.
Abstract: To determine whether infection with a Helicobacter pylori strain possessing cagA is associated with an increased risk of development of adenocarcinoma of the stomach, we used a nested case-control study based on a cohort of 5443 Japanese-American men in Oahu, Hawaii, who had a physical examination and a phlebotomy during 1967 to 1970 We matched 103 H pylori -infected men who developed gastric cancer during a 21-year surveillence period with 103 H pylori -infected men who did not develop gastric cancer and tested stored serum specimens from patients and controls for the presence of serum IgG to the cagA product of H pylori using an ELISA The serum IgG assay using a recombinant CagA fragment had a sensitivity of 944% and a specificity of 925% when used in a clinically defined population; serological results were stable for more than 7 years For men with antibodies to CagA, the odds ratio of developing gastric cancer was 19 (95% confidence interval, 09–40); for intestinal type cancer of the distal stomach, the odds ratio was 23 (95% confidence interval, 10–52) Age cagA -positive H pylori strain in comparison with a cagA -negative strain somewhat increases the risk for development of gastric cancer, especially intestinal type affecting the distal stomach
1,635 citations
Cites methods from "Ascertainment of men of Japanese an..."
...The study design of the Japan-Hawaii cohort (34) and our previous investigations of the association (OR = 6....
[...]
TL;DR: The inverse relation of alpha cholesterol of prevalence of coronary heart disease was independent of beta cholesterol, obesity, and other factors, and the need for further evaluation of the protective effect of the alpha lipoprotein fraction on the development of coronaryHeart disease is suggested.
Abstract: To ascertain the frequency of defined hyperlipoproteinemia and to investigate the relation between lipoprotein fractions and coronary heart disease, we measured serum lipoprotein cholesterol levels in a population-based sample of Hawaii Japanese men 50 to 72 years old. Type II hyperlipoproteinemia was present in 3 per cent of 1859 men, and Type IV in 26 per cent. Relative risks for coronary heart disease, based on 264 prevalence cases, were found to be 1.8, 1.8 and 0.46, between the upper and lower quartiles of total, beta, and alpha cholesterol, respectively. We found no significant relation between triglyceride and coronary heart disease. The inverse relation of alpha cholesterol of prevalence of coronary heart disease was independent of beta cholesterol, obesity, and other factors. The data suggest the need for further evaluation of the protective effect of the alpha lipoprotein fraction on the development of coronary heart disease.
876 citations
TL;DR: Long-lived men presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls, several of these aging phenotypes were associated with FOXO3A genotype.
Abstract: Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging phenotypes, and we performed a nested-case control study of 5 candidate longevity genes. Genetic variation within the FOXO3A gene was strongly associated with human longevity. The OR for homozygous minor vs. homozygous major alleles between the cases and controls was 2.75 (P = 0.00009; adjusted P = 0.00135). Long-lived men also presented several additional phenotypes linked to healthy aging, including lower prevalence of cancer and cardiovascular disease, better self-reported health, and high physical and cognitive function, despite significantly older ages than controls. Several of these aging phenotypes were associated with FOXO3A genotype. Long-lived men also exhibited several biological markers indicative of greater insulin sensitivity and this was associated with homozygosity for the FOXO3A GG genotype. Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations.
856 citations
Cites methods from "Ascertainment of men of Japanese an..."
...The HHP cohort has been described elsewhere (62)....
[...]
TL;DR: Differences in risk-factor burden translate into marked differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts.
Abstract: Background The lifetime risks of cardiovascular disease have not been reported across the age spectrum in black adults and white adults. Methods We conducted a meta-analysis at the individual level using data from 18 cohort studies involving a total of 257,384 black men and women and white men and women whose risk factors for cardiovascular disease were measured at the ages of 45, 55, 65, and 75 years. Blood pressure, cholesterol level, smoking status, and diabetes status were used to stratify participants according to risk factors into five mutually exclusive categories. The remaining lifetime risks of cardiovascular events were estimated for participants in each category at each age, with death free of cardiovascular disease treated as a competing event. Results We observed marked differences in the lifetime risks of cardiovascular disease across risk-factor strata. Among participants who were 55 years of age, those with an optimal risk-factor profile (total cholesterol level, <180 mg per deciliter [4.7...
773 citations
References
More filters
1,695 citations
1,104 citations
Journal Article•
314 citations
TL;DR: Two years ago, at the meeting of the College in Philadelphia, these data were in conformity with the hypothesis that dietary fat is an impo...
Abstract: Excerpt Two years ago, at the meeting of the College in Philadelphia, we reported some of our findings in South Africa. These data were in conformity with the hypothesis that dietary fat is an impo...
223 citations
TL;DR: Thrombotic brain infarction was much more common accounting for 63% of all "stroke" events than either subarachnoid hemorrhage and embolus to the brain or the most lethal type hemorrhage into the brain which occurred only 4% of the time.
Abstract: The epidemiologic features of thrombotic brain infarction in comparison to myocardial infarction both presumed manifestations of atherosclerosis were studied over a 12-year period in 5106 men and women aged 30-62. All were examined prior to the study and found to be free of both coronary heart disease and vascular disease of the brain. In the 12-year period 167 myocardial infarctions and 57 thrombotic brain infarctions occurred. A marked male predominance was noted in myocardial infarction but no predominance of either sex was noted in thrombotic infarction of the brain. In men only the incidence of brain infarction lagged 20 years behind that of myocardial infarction. Thrombotic brain infarction was much more common accounting for 63% of all "stroke" events than either subarachnoid hemorrhage and embolus to the brain or the most lethal type hemorrhage into the brain which occurred only 4% of the time. The incidence of both myocardial and thrombotic brain infarction increased with age. High risk factors included elevated blood pressure or serum cholesterol electrocardiographic abnormalities excessive smoking and a low vital energy. Generally the factors which predisposed to the development of the 1 disease also predisposed to the development of the other. Persons with any 2 of the high risk factors were usually susceptible. Obesity was not a risk factor in either disease.
208 citations