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Journal ArticleDOI

Assafoetidin and ferocolicin, two sesquiterpenoid coumarins from ferula assafoetida regel

01 Jan 1988-Tetrahedron Letters (TETRAHEDRON LETTERS)-Vol. 29, Iss: 13, pp 1557-1560
TL;DR: A new sesquiterpenoid coumarin is isolated from the gum resin of Ferula sasafoetida and ferocolicin was observed for the first time to occur in this species.
About: This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 27 citations till now.
Citations
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Journal ArticleDOI
TL;DR: The present review summarizes the information concerning the traditional uses, phytochemistry and biological activities of asafoetida, an oleo-gum-resin obtained from the roots of different Ferula assa-foetida.

215 citations

Journal ArticleDOI
TL;DR: Two new sesquiterpene coumarins were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation and showed greater potency against influenza A virus than amantadine and exhibited the best potency against HepG2, Hep3B, and MCF-7 cancer cell lines.
Abstract: Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1-3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6-13 showed greater potency against influenza A virus (H(1)N(1)) (IC(50) 0.26-0.86 microg/mL) than amantadine (IC(50) 0.92 microg/mL), and 11 exhibited the best potency (IC(50) 0.51, 2.6, and 3.4 microg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively.

178 citations

Journal ArticleDOI
TL;DR: From the chloroform extract of the roots of Ferula assa-foetida, two sesquiterpene coumarins designated assafoetidnol A and assafosin were isolated, in addition to six known compounds, gummosin, polyanthin, badrakemin, neveskone, samarcandin and galbanic acid.

89 citations

Journal ArticleDOI
TL;DR: Phytochemistry and various pharmacological and clinical studies of asafoetida, a strong, tenacious and sulfurous odor, and oleo-gum resin of medicinal and nutritional importance, are reviewed.

79 citations

Book ChapterDOI
TL;DR: 7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarin.
Abstract: Over the past 150 years, since Vogel in 1820 isolated the parent oxygen heterocycle, coumarin (1) from Coumarouna odorata = Dipteryx odorata (1), coumarins have been recognized as widely distributed plant products. The vast majority carry an oxygen substituent at C-7; consequently 7-hydroxycoumarin [umbelliferone, (2)], one of the most widely distributed coumarins, is often regarded as the parent, in a structural sense and also biogenetically, of a large number of the structurally more complex coumarins. A number of review articles on natural plant coumarins have appeared (154, 302, 344, 420, 525, 541, 548) since the last in this series (153), the most comprehensive, albeit dealing solely with coumarins of the Umbelliferae, being that of Nielsen in 1970 (419).

77 citations

References
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Book
01 Jan 1983
TL;DR: In this paper, the authors present tables and charts of spectrum-structure correlations for all major spectroscopic techniques (C13 NMR, 1H-NMR, IR, MS, UV/VIS).
Abstract: "This book contains tables and charts of spectrum-structure correlations for all major spectroscopic techniques (C13-NMR, 1H-NMR, IR, MS, UV/VIS). It has been designed for those who are routinely faced with the task of interpreting this type of spectral information. ...

987 citations

Book
01 Jan 1983

519 citations

Journal ArticleDOI
TL;DR: In this article, complete assignments of chemical shifts and extensive assignments of carbon-proton coupling constants are presented for all the monohydroxycoumarins except the 5-derivative.

98 citations

Journal ArticleDOI
TL;DR: A new sesquiterpenoid coumarin, foetidin, has been isolated from the roots of Ferula assa-foetida as discussed by the authors, which is derived from the same root.

23 citations