Assessing the quality of reports of randomized clinical trials : is blinding necessary?
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...Random allocation Blinding Clear/validated outcomes Description of withdrawals and dropouts Clear hypothesis and objectives Clear inclusion/exclusion criteria Power calculation Appropriate size Intention to treat Single observer Adequate follow-up Negative/positive controls Controlled cointerventions Appropriate analysis Randomization method explained Description of investigators and assessors Description of interventions Raw data available Compliance check Adverse effects documented clearly Comparable groups Clinical relevance Protocol is followed Informed consent Adequate analysis Appropriate outcome measures Data supporting conclusions Paper clear and simple to understand Ethical approval Appropriate study Independent study Overall impression Prospective study More than 1 assessment time Attempt to demonstrate dose response with new agents Appropriate duration of study Description of selection method Definition of method to record adverse effects Definition of methods for adverse effect management Objective outcome measurements Avoidance of data unrelated to the question addressed Representative sample Statistics, central tendency, and dispersion measures reported Blinding testing Results of randomization reported Analysis of impact of withdrawals Clear tables Clear figures Clear retrospective analysis (5) (5) (5) (5) (4) (4) (4) (3) (3) (3) (3) (3) (3) (3) (2) (2) (2) (2) (2) (2) (2) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) (1) 0) (1) (1) (1) 0) (1) (1) 0) 0) (1)...
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