Association Between Ustekinumab Trough Concentrations and Clinical, Biomarker, and Endoscopic Outcomes in Patients With Crohn's Disease
Citations
237 citations
189 citations
Cites background from "Association Between Ustekinumab Tro..."
...The current evidence supporting the role of TDM regarding ustekinumab is based on 2 exposure-response relationship studies showing that higher ustekinumab concentrations correlate to better therapeutic outcomes (Table 2).(49,89) At this time, there are still no studies comparing either proactive or reactive TDM with empiric ustekinumab optimization....
[...]
156 citations
126 citations
121 citations
Additional excerpts
...The role of ustekinumab pharmacokinetics is unclear at this moment, but cohort data suggest that endoscopic healing is related to ustekinumab trough levels [13], which was also observed in a post hoc sub-analysis of the phase III program [14]....
[...]
References
3,870 citations
2,937 citations
2,059 citations
2,028 citations
[...]
1,700 citations
"Association Between Ustekinumab Tro..." refers background in this paper
...Crohn’s disease (CD) is a chronic debilitating inflammatory bowel disease.(1) In patients receiving anti–tumor necrosis factor (anti-TNF) medications, up to two-thirds have either primary nonresponse or secondary loss of response....
[...]