Association of asthma and its genetic predisposition with the risk of severe COVID-19.
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In a large population-based cohort data, adults with asthma had a higher risk of severe COVID-19, which was driven by the increased risk among patients with non-allergic asthma.Abstract:
Summary In a large population-based cohort data, adults with asthma had a higher risk of severe COVID-19, which was driven by the increased risk among patients with non-allergic asthma.read more
Citations
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Risk factors for severe and critically ill COVID-19 patients: A review.
Ya-dong Gao,Mei Ding,Mei Ding,Xiang Dong,Jin-jin Zhang,Ahmet Kursat Azkur,Dilek Azkur,Hui Gan,Yuan-Li Sun,Wei Fu,Wei Li,Hui-ling Liang,Yiyuan Cao,Qi Yan,Can Cao,Hong-yu Gao,Marie-Charlotte Brüggen,Willem van de Veen,Milena Sokolowska,Mübeccel Akdis,Cezmi A. Akdis +20 more
TL;DR: In this review, the scientific evidence on the risk factors of severity of COVID‐19 are highlighted and socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day of initiation of treatment, and quality of health care have been reported to influence individual outcomes.
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Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study.
Jee Myung Yang,Hyun Yong Koh,Sung Yong Moon,In Kyung Yoo,Eun Kyo Ha,Seulgi You,So-Young Kim,Dong Keon Yon,Seung Won Lee +8 more
TL;DR: It is found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 positivity.
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Body Mass Index and Risk for Intubation or Death in SARS-CoV-2 Infection : A Retrospective Cohort Study.
Michaela R. Anderson,Joshua Geleris,David Anderson,Jason Zucker,Yael R. Nobel,Daniel E. Freedberg,Jennifer L. Small-Saunders,Kartik N. Rajagopalan,Richard A. Greendyk,Sae Rom Chae,Karthik Natarajan,David Roh,Ethan Edwin,Dympna Gallagher,Anna J. Podolanczuk,R. Graham Barr,Anthony W. Ferrante,Matthew R. Baldwin +17 more
TL;DR: This study examines whether obesity is associated with intubation or death—as well as biomarkers of inflammation, cardiac injury, or fibrinolysis—in the context of COVID-19 disease independent of obesity-related comorbidities.
Journal ArticleDOI
Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK.
Chloe I Bloom,Thomas M Drake,Annemarie B Docherty,Brian J. Lipworth,Sebastian L. Johnston,Jonathan S. Nguyen-Van-Tam,Gail Carson,Jake Dunning,Jake Dunning,Ewen M Harrison,J Kenneth Baillie,Malcolm G Semple,Malcolm G Semple,Paul Cullinan,Peter J. M. Openshaw,Beatrice Alex,Benjamin Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Ana da Silva Filipe,Tom Fletcher,Christoper A Green,Julian A. Hiscox,Antonia Ying Ho,Peter Horby,Samreen Ijaz,Saye Khoo,Paul Klenerman,Andy Law,Wei Shen Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Shona C Moore,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Clark D Russell,Vanessa Sancho-Shimizu,Janet T Scott,Thushan I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,Charlotte Summers,Richard S. Tedder,E. Thomson,A. A. Roger Thompson,Ryan S Thwaites,Lance Turtle,Maria Zambon,Hayley E Hardwick,Chloe Donohue,Ruth Lyons,Fiona Griffiths,Wilna Oosthuyzen,Lisa Norman,Riinu Pius,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,Catherine A Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stephanie Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Clare Jackson,Carrol Gamble,Gary Leeming,Murray Wham,Sara Clohisey,Ross Hendry,James Scott-Brown,William Greenhalf,Victoria Shaw,Sara McDonald,Seán Keating,Katie A. Ahmed,Jane A Armstrong,Milton Ashworth,Innocent G Asiimwe,Siddharth Bakshi,Samantha L Barlow,Laura Booth,Benjamin Brennan,Katie Bullock,Benjamin Wa Catterall,Jordan J. Clark,Emily A Clarke,Sarah Cole,Louise Cooper,Helen Cox,Chris Davis,Oslem Dincarslan,Chris Dunn,P.A. Dyer,Angela Elliott,Anthony Evans,Lorna Finch,Lewis Ws Fisher,Terry Foster,Isabel García-Dorival,Philip Gunning,Catherine Hartley,Rebecca L Jensen,Christopher B Jones,Trevor R Jones,Shadia Khandaker,Katharine King,Robyn T. Kiy,Chrysa Koukorava,Annette Lake,Suzannah Lant,Diane Latawiec,Lara Lavelle-Langham,Daniella Lefteri,Lauren Lett,Lucia A Livoti,Maria Mancini,Sarah E. McDonald,Laurence McEvoy,John McLauchlan,Soeren Metelmann,Nahida S Miah,Joanna Middleton,Joyce Mitchell,Ellen G Murphy,Rebekah Penrice-Randal,Jack Pilgrim,Tessa Prince,Will Reynolds,P. Matthew Ridley,Debby Sales,Victoria E Shaw,Rebecca K Shears,Benjamin Small,Krishanthi Subramaniam,Agnieska Szemiel,Aislynn Taggart,Jolanta Tanianis-Hughes,Jordan Thomas,Erwan Trochu,Libby van Tonder,Eve Wilcock,J. Eunice Zhang,Lisa Flaherty,Nicole Maziere,Emily Cass,Alejandra Doce Carracedo,Nicola Carlucci,Anthony Holmes,Hannah Massey,Kayode Adeniji,Daniel Agranoff,Ken Agwuh,Dhiraj Ail,Ana Alegria,Brian Angus,Abdul Ashish,Dougal Atkinson,Shahedal Bari,Gavin Barlow,Stella Barnass,Nicholas A Barrett,Christopher Bassford,David Baxter,Michael Beadsworth,Jolanta Bernatoniene,John Berridge,Nicola Best,Pieter Bothma,David Brealey,Robin Brittain-Long,Naomi Bulteel,Tom Burden,Andrew Burtenshaw,Vikki Caruth,David Chadwick,Duncan Chambler,Nigel Chee,Jenny Child,Srikanth Chukkambotla,Thomas A. Clark,Paul Collini,Catherine Cosgrove,Jason Cupitt,Maria-Teresa Cutino-Moguel,Paul Dark,Chris Dawson,Samir Dervisevic,Phil Donnison,Sam Douthwaite,Ingrid DuRand,Ahilanadan Dushianthan,Tristan Dyer,Cariad Evans,Chi Eziefula,Chrisopher Fegan,Adam Finn,Duncan Fullerton,Sanjeev Garg,Atul Garg,Effrossyni Gkrania-Klotsas,Jo Godden,Arthur Goldsmith,Clive Graham,Elaine Hardy,Stuart Hartshorn,Daniel Harvey,Peter Havalda,Daniel B Hawcutt,Maria Hobrok,Luke Hodgson,Anil Hormis,Michael Jacobs,Susan Jain,Paul Jennings,Agilan Kaliappan,Vidya Kasipandian,Stephen Kegg,Michael Kelsey,Jason Kendall,Caroline Kerrison,Ian Kerslake,Oliver Koch,Gouri Koduri,George Koshy,Shondipon Laha,Steven Laird,Susan Larkin,Tamas Leiner,Patrick J. Lillie,James Limb,Vanessa Linnett,Jeff Little,Michael MacMahon,Emily MacNaughton,Ravish Mankregod,Huw Masson,Elijah Matovu,Katherine McCullough,Ruth McEwen,Manjula Meda,Gary H. Mills,Jane Minton,Mariyam Mirfenderesky,Kavya Mohandas,Quen Mok,James Moon,Elinoor Moore,Patrick Morgan,Craig Morris,Katherine Mortimore,Samuel Moses,Mbiye Mpenge,Rohinton Mulla,Michael Murphy,Megan Nagel,Thapas Nagarajan,Mark T. Nelson,Igor Otahal,Mark Pais,Selva Panchatsharam,Hassan Paraiso,Brij Patel,Natalie Pattison,Justin Pepperell,Mark J. Peters,Mandeep Phull,Stefania Pintus,Jagtur Singh Pooni,Frank A. Post,David Price,Rachel Prout,Nikolas Rae,Henrik Reschreiter,Tim Reynolds,Neil Richardson,Mark Roberts,Devender Roberts,Alistair Rose,Guy Rousseau,Brendan Ryan,Taranprit Saluja,Aarti Shah,Prad Shanmuga,Anil Sharma,Anna Shawcross,Jeremy Sizer,Manu Shankar-Hari,Richard Smith,Catherine Snelson,Nick Spittle,Nikki Staines,Tom Stambach,Richard Stewart,Pradeep Subudhi,Tamas Szakmany,Kate Tatham,Jo Thomas,Chris Thompson,Robert Thompson,Ascanio Tridente,Darell Tupper-Carey,Mary Twagira,Andrew Ustianowski,Nick Vallotton,Lisa Vincent-Smith,Shico Visuvanathan,Alan Vuylsteke,Sam Waddy,Rachel Wake,Andrew Walden,Ingeborg Welters,Tony Whitehouse,Paul Whittaker,Ashley Whittington,Meme Wijesinghe,Martin S. Williams,Lawrence Wilson,Sarah Wilson,Stephen Winchester,Martin Wiselka,Adam Wolverson,Daniel G Wooton,Andrew Workman,Bryan Yates,Peter Young +339 more
TL;DR: In this paper, the effect of inhaled corticosteroid use in patients admitted to hospital with COVID-19 with underlying respiratory conditions was examined. But, the results were limited to patients aged 50 years and older and not for those with chronic pulmonary disease.
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Factors Associated with Hospitalization and Disease Severity in a Racially and Ethnically Diverse Population of COVID-19 Patients
TL;DR: This study confirms race and ethnicity as predictors of severe COVID-19 and identifies clinical risk factors not previously reported such as vitamin D deficiency, hypercholesterolemia, osteoarthritis, and anemia.
References
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TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
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Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020.
Shikha Garg,Shikha Garg,Lindsay Kim,Michael Whitaker,Alissa O’Halloran,Charisse N Cummings,Rachel Holstein,Mila M. Prill,Shua J Chai,Pam Daily Kirley,Nisha B Alden,Breanna Kawasaki,Kimberly Yousey-Hindes,Linda M. Niccolai,Evan J. Anderson,Evan J. Anderson,Kyle P Openo,Andrew Weigel,Maya Monroe,Patricia Ryan,Justin Henderson,Sue Kim,Kathy Como-Sabetti,Ruth Lynfield,Daniel M. Sosin,Salina Torres,Alison Muse,Nancy M. Bennett,Laurie M Billing,Melissa Sutton,Nicole West,William Schaffner,H. Keipp Talbot,Clarissa Aquino,Andrea George,Alicia P Budd,Lynnette Brammer,Gayle E Langley,Aron J. Hall,Alicia M. Fry +39 more
TL;DR: It is suggested that older adults have elevated rates of COVID-19-associated hospitalization and the majority of persons hospitalized with CO VID-19 have underlying medical conditions, which underscore the importance of preventive measures to protect older adults and persons with underlyingmedical conditions, as well as the general public.
Journal ArticleDOI
Clinical Characteristics of Covid-19 in New York City.
Parag Goyal,Justin J Choi,Laura C. Pinheiro,Edward J. Schenck,Ruijun Chen,Assem Jabri,Michael J. Satlin,Thomas R. Campion,Musarrat Nahid,Joanna Bryan Ringel,Katherine Hoffman,Mark N. Alshak,Han A Li,Graham T Wehmeyer,Mangala Rajan,Evgeniya Reshetnyak,Nathaniel Hupert,Evelyn M. Horn,Fernando J. Martinez,Roy M. Gulick,Monika M. Safford +20 more
TL;DR: In this series of 393 consecutive patients admitted with Covid-19 to two New York City hospitals from March 3 to March 27, a third of patients received invasive mechanical ventilation treatment.
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