Association of human papillomavirus and p16 status with mucositis and dysphagia for head and neck cancer patients treated with radiotherapy with or without cetuximab: Assessment from a phase 3 registration trial
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Cites background from "Association of human papillomavirus..."
...Finally, they have also seen that patients with p16 negative seem to develop more frequently grade 3 or 4 mucositis (Bonner et al., 2016)....
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103 citations
Cites background from "Association of human papillomavirus..."
...reported that, regardless of p16 status, the addition of cetuximab to cervical radiotherapy did not impact the incidence, time to onset, severity, or duration of mucositis [132] (Table 2)....
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...Cetuximab in association with head and neck radiation therapy The incidence of high-grade (≥3) mucositis is high when cetuximab is combined with radiotherapy (about 60%) [73, 75, 132]....
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...The main pivotal studies [73, 75, 132] (Table 2), however, indicate that the addition of cetuximab to radiotherapy does not have a significant impact on the incidence of high-grade (≥3) mucositis in comparison to radiotherapy alone [73–75] (Table 2)....
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71 citations
Cites background from "Association of human papillomavirus..."
...In patients with HNC undergoing concomitant treatment with RT associated with cetuximab, a p16-negative status seems to be associated with a higher rate of grade 3–4 OM [87]....
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References
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"Association of human papillomavirus..." refers methods in this paper
...Toxicity was assessed using the Radiation Therapy Oncology Group (RTOG) criteria [8]....
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1,784 citations
"Association of human papillomavirus..." refers methods in this paper
...The design of the phase 3, randomized IMCL-9815 cetuximab registration trial has previously been reported in detail [6,7]....
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1,436 citations
"Association of human papillomavirus..." refers background in this paper
...Furthermore, HPV-negative patients were more likely to have greater tobacco exposure and more comorbidities than their HPV-positive counterparts [17], which may have contributed to the need for feeding tubes....
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1,022 citations
"Association of human papillomavirus..." refers background in this paper
...Radiotherapy (RT) for locally advanced head and neck squamous cell carcinoma (LA-SCCHN) can induce mucositis, pain, dysphagia, and diminished quality of life [1,2]....
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