Association of Hyperensive Disorders and Diabetes with Pregnancy in Women with Polycystic Ovary Syndrome

TLDR: Hypertensive disorders of pregnancy like gestational hypertension, preeclampsia and chronic hypertension and diabetes (both gestational diabetes and overt diabetes) were significantly increased in women with PCOS compared to the control group.

Abstract: Background: Women with PCOS are at an increased risk of metabolic disorders in pregnancy, such as impaired fasting glucose, gestational diabetes and hypertensive disorders of pregnancy. These morbidities, individually or combined, affect pregnancy outcome in these women. Objective: To evaluate the association of diabetes and hypertensive disorders with pregnancy in women with polycystic ovary syndrome. Materials and Methods: This is a prospective cohort study conducted over a period of one year. Antenatal women attending the Govt medical college, Trivandrum and diagnosed to have polycystic ovarian syndrome according to Rotterdam criteria were included in the study. For comparison we selected same number of pregnant women without any features of PCOS. Student ttest or Chi-square test were used to test the difference between PCOS and non PCOS group. Results: Hypertensive disorders in patients with PCOS is statistically significant with p<0.015 and with Relative Risk (95% CI)= 2.0 (1.121-3.567). Significant number of cases with PCOS (69.9%) had diabetes mellitus in pregnancy compared to control group (27.3%). Conclusion: Hypertensive disorders of pregnancy like gestational hypertension, preeclampsia and chronic hypertension and diabetes (both gestational diabetes and overt diabetes) were significantly increased in women with PCOS compared to the control group.