Association study designs for complex diseases
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Cites background from "Association study designs for compl..."
...The Mendelian randomization approach requires reliable estimation of the associations between genotype and the modifiable exposure of interest and between genotype and the outcome of interest, but it is well recognized that genetic association studies often fail to replicate [81–83]....
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Cites background from "Association study designs for compl..."
..., but are plagued by the impression that they are not consistently reproducibl...
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Cites background from "Association study designs for compl..."
...…genetic-marker maps, particularly those with single-nucleotide polymorphisms (SNPs) (The International SNP Map Working Group 2001), association studies will improve our ability to detect susceptibility alleles for common complex diseases (Risch 2000; Cardon and Bell 2001; Schork et al. 2001)....
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...It is anticipated that, by use of improved genetic-marker maps, particularly those with single-nucleotide polymorphisms (SNPs) (The International SNP Map Working Group 2001), association studies will improve our ability to detect susceptibility alleles for common complex diseases (Risch 2000; Cardon and Bell 2001; Schork et al. 2001)....
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