Journal ArticleDOI
Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?
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TLDR
A case can be made that psoriasis and AD exist across a spectrum where polar T-cell axes can be variably present and create some overlapping disease characteristics, and an outstanding question is whether targeting a single cytokine axis in AD will lead to disease suppression in the majority of patients and across all subtypes.About:
This article is published in Current Opinion in Immunology.The article was published on 2017-10-01. It has received 229 citations till now. The article focuses on the topics: Psoriasis & Disease.read more
Citations
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Journal ArticleDOI
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Lam C. Tsoi,Elke Rodriguez,Frauke Degenhardt,Hansjörg Baurecht,Ulrike Wehkamp,Natalie Volks,Silke Szymczak,William R. Swindell,Mrinal K. Sarkar,Kalpana Raja,Shuai Shao,Matthew Patrick,Yilin Gao,Ranjitha Uppala,Bethany E. Perez White,Spiro Getsios,Paul W. Harms,Emanual Michael Maverakis,James T. Elder,James T. Elder,Andre Franke,Johann E. Gudjonsson,Stephan Weidinger +22 more
TL;DR: This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Journal ArticleDOI
Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021.
TL;DR: In this article, an association between moderate intake of the omega-6 PUFA linoleic acid and lower risk of cardiovascular diseases (CVDs), most likely as a result of lower blood cholesterol concentration.
Journal ArticleDOI
Developmental cell programs are co-opted in inflammatory skin disease
Gary Reynolds,Peter Vegh,James Fletcher,Elizabeth Poyner,Emily Stephenson,Issac Goh,Rachel A. Botting,Ni Huang,Bayanne Olabi,Bayanne Olabi,Anna Dubois,David Dixon,Kile Green,Daniel Maunder,Justin Engelbert,Mirjana Efremova,Krzysztof Polanski,Laura Jardine,C Jones,Thomas Ness,Dave Horsfall,Jim McGrath,Christopher D. Carey,Dorin-Mirel Popescu,Simone Webb,Xiao-Nong Wang,Ben Sayer,Jong-Eun Park,Victor A. Negri,Daria Belokhvostova,Magnus D. Lynch,David McDonald,Andrew Filby,Tzachi Hagai,Kerstin B. Meyer,A. Husain,Jonathan Coxhead,Roser Vento-Tormo,Sam Behjati,Sam Behjati,Steven Lisgo,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jaume Bacardit,Philip H. Jones,Philip H. Jones,Edel A. O'Toole,Graham S. Ogg,Neil Rajan,Nick J. Reynolds,Sarah A. Teichmann,Sarah A. Teichmann,Fiona M. Watt,Muzlifah Haniffa,Muzlifah Haniffa +54 more
TL;DR: In this paper, the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis were compared across development, homeostasis, and disease.
Journal ArticleDOI
Eosinophils from Physiology to Disease: A Comprehensive Review.
Giuseppe A. Ramirez,Mona-Rita Yacoub,Marco Ripa,Daniele Mannina,Adriana Cariddi,Nicoletta Saporiti,Fabio Ciceri,Antonella Castagna,Giselda Colombo,Lorenzo Dagna +9 more
TL;DR: A comprehensive update on the pathophysiological role of eosinophils in host defence, inflammation, and cancer is provided and potential clinical implications are discussed in light of recent therapeutic advances.
References
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Journal ArticleDOI
Mechanisms of Disease: Psoriasis.
TL;DR: Anti-TNF strategies have three variants: a humanized chimeric anti–TNF- α monoclonal antibody, a fully human monocolonal anti-T NF- α antibody, and a human p75 TNF-receptor Fc fusion protein.
Journal ArticleDOI
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson,Thomas Bieber,Emma Guttman-Yassky,Lisa A. Beck,Andrew Blauvelt,Michael J. Cork,Jonathan I. Silverberg,Mette Deleuran,Yoko Kataoka,Jean-Philippe Lacour,Külli Kingo,Margitta Worm,Margitta Worm,Yves Poulin,Andreas Wollenberg,Yuhwen Soo,Neil M.H. Graham,Gianluca Pirozzi,Bolanle Akinlade,Heribert Staudinger,Vera Mastey,Laurent Eckert,Abhijit Gadkari,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +25 more
TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.
Journal ArticleDOI
Immunology of Psoriasis
TL;DR: The genetic background of psoriasis and its relationship to immune function, specifically genetic mutations, key PSORS loci, single nucleotide polymorphisms, and the skin transcriptome are discussed.
Journal ArticleDOI
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
Lisa A. Beck,Diamant Thaçi,Jennifer D. Hamilton,Neil M.H. Graham,Thomas Bieber,Ross E. Rocklin,Jeffrey Ming,Haobo Ren,Richard Kao,Eric L. Simpson,Marius Ardeleanu,Steven P. Weinstein,Gianluca Pirozzi,Emma Guttman-Yassky,Mayte Suárez-Fariñas,Melissa D. Hager,Neil Stahl,George D. Yancopoulos,Allen Radin +18 more
TL;DR: Patients treated with dupilumab had marked and rapid improvement in all the evaluated measures of atopic dermatitis disease activity, and side-effect profiles were not dose-limiting.
Journal ArticleDOI
Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.
Kristine E. Nograles,Lisa C. Zaba,Emma Guttman-Yassky,Judilyn Fuentes-Duculan,Mayte Suárez-Fariñas,Irma Cardinale,Artemis Khatcherian,Juana Gonzalez,Katherine C. Pierson,Traci R. White,Cara A. Pensabene,Israel Coats,Inna Novitskaya,Michelle A. Lowes,James G. Krueger +14 more
TL;DR: This data indicates that suppression of Th1 and Th17 cytokines in Psoriasis vulgaris is a pro-inflammatory disease and the relative contribution of interferon, IFN,γ, interleukin and IL‐22 on disease pathogenesis is still unknown.
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