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Aulton's Pharmaceutics : The Design and Manufacture of Medicines

ME Aulton, Kevin M.G. Taylor
01 Jan 2013-
TL;DR: What is 'pharmaceutics'?
Abstract: What is 'pharmaceutics'? Design of dosage forms PART ONE: SCIENTIFIC PRINCIPLES OF DOSAGE FORM DESIGN *Dissolution and solubility *Properties of solutions *Rheology *Surface and interfacial phenomena *Disperse systems *Kinetics of product stability PART TWO: PARTICLE SCIENCE AND POWDER TECHNOLOGY *Solid-state properties *Particle size analysis *Particle size reduction *Particle size separation *Mixing *Powder flow. PART THREE: PHARMACEUTICAL MICROBIOLOGY AND STERILIZATION *Fundamentals of microbiology *Pharmaceutical applications of microbiological techniques *Action of physical and chemical agents on microorganisms *Principles of sterilization *Sterilization in practice PART FOUR: BIOPHARMACEUTICAL PRINCIPLES OF DRUG DELIVERY *Introduction to biopharmaceutics *Gastrointestinal tract - physiology and drug absorption *Bioavailability - physicochemical and dosage form factors *Assessment of biopharmaceutical properties *Dosage regimens PART FIVE: DOSAGE FORM DESIGN AND MANUFACTURE *Pharmaceutical preformulation *Solutions *Clarification *Suspensions and emulsions *Powders and granules *Granulation *Drying *Tablets and compaction *Modified-release peroral dosage forms *Coating of tablets and multiparticulates *Hard gelatin capsules *Soft gelatin capsules *Pulmonary drug delivery *Nasal drug delivery *Transdermal drug delivery *Wound dressings *Rectal and vaginal drug delivery *Delivery of pharmaceutical proteins *Packs and packaging *Microbial contamination, spoilage and preservation of medicines *Product stability and stability testing *Pharmaceutical plant design *Heat transfer and the properties and use of steam
Citations
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Journal Article•DOI•
Biomedical applications of hydrogels: A review of patents and commercial products

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Enrica Caló1, Vitaliy V. Khutoryanskiy1•
University of Reading1
01 Apr 2015-European Polymer Journal
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.

1,788 citations

Journal Article•DOI•
Nanoemulsion: Concepts, development and applications in drug delivery

[...]

Yuvraj Singh1, Jaya Gopal Meher1, Kavit Raval1, Farooq Ali Khan1, Mohini Chaurasia2, Nitin Jain3, Manish K. Chourasia1 •
Central Drug Research Institute1, Amity University2, Department of Biotechnology3
28 Apr 2017-Journal of Controlled Release
TL;DR: This work attempts to explore varying intricacies, excipients, manufacturing techniques and their underlying principles, production conditions, structural dynamics, prevalent destabilization mechanisms, and drug delivery applications of nanoemulsions to spike interest of those contemplating a foray in this field.

707 citations

Journal Article•DOI•
Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs

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Shrawan Baghel1, Helen Cathcart1, Niall J. O’Reilly1•
Waterford Institute of Technology1
01 Sep 2016-Journal of Pharmaceutical Sciences
TL;DR: This review attempts to address the critical molecular and thermodynamic aspects governing the physicochemical properties of amorphous solid dispersion systems and potential advantage of polymers as inert, hydrophilic, pharmaceutical carrier matrices.

680 citations

Cites background from "Aulton's Pharmaceutics : The Design..."

  • ...13 On the basis of the distribution of the drug molecules in the carrier matrix, solid dispersions can be divided into 3 types: (1) Eutectic systems are mixtures of 2 compounds in a specific ratio and have a single melting point which is lower than the melting points of the individual components; (2) Solid solutions which are further divided into substitutional solid solutions (solute molecule replaces a solvent molecule), interstitial solid solutions (solute molecule is present in the interstices), and amorphous solid solutions having solute randomly distributed in an amorphous carriers; and (3) Microfine crystalline dispersions are crystalline dispersion of drugs in the carrier matrix....

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Journal Article•DOI•
A new chapter in pharmaceutical manufacturing: 3D-printed drug products.

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James J. Norman1, Rapti D. Madurawe1, Christine M. V. Moore2, Mansoor A. Khan3, Akm Khairuzzaman1 •
Center for Drug Evaluation and Research1, United States Military Academy2, Texas A&M Health Science Center3
01 Jan 2017-Advanced Drug Delivery Reviews
TL;DR: It is believed that the recent approval of a 3D printed drug product will stimulate continual innovation in pharmaceutical manufacturing technology and highlight how product and process understanding can facilitate the development of a control strategy for different 3D printing methods.

544 citations

Cites background from "Aulton's Pharmaceutics : The Design..."

  • ...The solidification mechanisms for binder deposition are identical to the mechanisms for wet granulation [21]: formation of binder-based bridges between particles or joining of particles by dissolution and re-crystallization....

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Journal Article•DOI•
A Review of Disintegration Mechanisms and Measurement Techniques.

[...]

Daniel Markl1, J. Axel Zeitler1•
University of Cambridge1
01 Mar 2017-Pharmaceutical Research
TL;DR: This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics and methods used to study the disintegration in-situ.
Abstract: Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically powder compacts consisting of several different excipients in addition to the API. Excipients are added to a formulation in order to achieve the desired fill weight of a dosage form, to improve the processability or to affect the drug release behaviour in the body. These complex porous systems undergo different mechanisms when they come in contact with physiological fluids. The performance of a drug is primarily influenced by the disintegration and dissolution behaviour of the powder compact. The disintegration process is specifically critical for immediate-release dosage forms. Its mechanisms and the factors impacting disintegration are discussed and methods used to study the disintegration in-situ are presented. This review further summarises mathematical models used to simulate disintegration phenomena and to predict drug release kinetics.

218 citations

Cites background from "Aulton's Pharmaceutics : The Design..."

  • ...1 Schematic of the drug release process from a tablet (modified from [207])....

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