Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe
Richard A. Schwarz,Wen Gao,Dania Daye,Michelle D. Williams,Rebecca Richards-Kortum,Ann M. Gillenwater +5 more
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TLDR
Results indicate that the addition of depth selectivity can enhance the detection of optical changes associated with precancer.Abstract:
Optical spectroscopy can provide useful diagnostic information about the morphological and biochemical changes related to the progression of precancer in epithelial tissue. As precancerous lesions develop, the optical properties of both the superficial epithelium and underlying stroma are altered; measuring spectral data as a function of depth has the potential to improve diagnostic performance. We describe a clinical spectroscopy system with a depth-sensitive, ball lens coupled fiber-optic probe for noninvasive in vivo measurement of oral autofluorescence and diffuse reflectance spectra. We report results of spectroscopic measurements from oral sites in normal volunteers and in patients with neoplastic lesions of the oral mucosa; results indicate that the addition of depth selectivity can enhance the detection of optical changes associated with precancer.read more
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Fluorescence Lifetime Techniques in Medical Applications
TL;DR: An overview of time-resolved (lifetime) fluorescence techniques used in biomedical diagnostics and evaluates whether intrinsic fluorescence signals provide useful contrast for the diagnosis of human diseases including cancer, skin and eye diseases, and atherosclerotic cardiovascular disease.
Dissertation
Fiber optic probes for biomedical optical spectroscopy
TL;DR: Optical spectroscopy has been well validated by the physical sciences as a method to characterize chemical compositions in biological material as mentioned in this paper, and it has also showed promising to detect atheroscleroti
Journal ArticleDOI
Noninvasive Evaluation of Oral Lesions Using Depth-Sensitive Optical Spectroscopy
Richard A. Schwarz,Wen Gao,Crystal Redden Weber,Cristina Kurachi,J. Jack Lee,Adel K. El-Naggar,Rebecca Richards-Kortum,Ann M. Gillenwater +7 more
TL;DR: The diagnostic performance of a depth‐sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non‐neoplastic oral mucosa is evaluated.
Journal ArticleDOI
Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities.
Ross D. Uthoff,Bofan Song,Sumsum P. Sunny,Sanjana Patrick,Amritha Suresh,Trupti Kolur,G. Keerthi,Oliver Spires,Afarin Anbarani,Petra Wilder-Smith,Moni Abraham Kuriakose,Praveen Birur,Rongguang Liang +12 more
TL;DR: The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity.
Journal ArticleDOI
Effectiveness of narrow band imaging in the detection of premalignant and malignant lesions of the larynx: Validation of a new endoscopic clinical classification
Giulia Bertino,Salvatore Cacciola,Wladir Bastos Fernandes,Carolina Muniz Fernandes,Antonio Occhini,Carmine Tinelli,Marco Benazzo +6 more
TL;DR: The purpose of this study was to assess the value of narrow band imaging (NBI) endoscopy in the diagnosis of pharyngolaryngeal lesions and to demonstrate the validity of a new NBI‐based classification of their vascular pattern.
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