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Journal ArticleDOI

Autogenous cancellous bone and marrow transplants.

01 Nov 1970-Clinical Orthopaedics and Related Research (Clin Orthop Relat Res)-Vol. 73, Iss: 6, pp 199-209
About: This article is published in Clinical Orthopaedics and Related Research.The article was published on 1970-11-01. It has received 156 citations till now. The article focuses on the topics: Cancellous bone & Mandible.
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TL;DR: In this paper, the authors described the preparation and use of platelet gel, an autologous formulation of fibrin glue, for reconstructive oral and maxillofacial surgery.

755 citations

Journal ArticleDOI
TL;DR: Biomechanical testing and radiographic evauation revealed that the addition of bone marrow aspirate was essential for tricalcium phosphate and hydroxyapatite to achieve results comparable with those of cancellous bone, and this degradation took place only after a degree of mechanical competence necessary for weight‐bearing was achieved.

231 citations

Journal ArticleDOI
TL;DR: Autologous fibrin adhesive proved to be a solution as demonstrated in a series of 33 cases and helped the remodeling process begin about 50% earlier by providing the substratum for migration of mesenchymal cells, accelerating revascularization and migration of fibroblasts, stimulating the growth of both fibro Blasts and osteoblasts, and slowing the multiplication of microorganisms.

221 citations

Journal ArticleDOI
TL;DR: In this paper, three different porous ceramics (calcium aluminate, calcium hydroxyapatite and tricalcium phosphate), with interlinked pores of two size ranges (150 to 210 micron), were implanted into the skulls of rats and rabbits for up to six months; the interaction with surrounding bone, which is virtually devoid of bone marrow, was assessed.
Abstract: Ceramics have many properties which might make them suitable alternatives to bone grafts. This present study was done to find a suitable biodegradable porous ceramic for human bone replacement. Three different porous ceramics (calcium aluminate, calcium hydroxyapatite and tricalcium phosphate), with interlinked pores of two size ranges (150 to 210 micron), were implanted into the skulls of rats and rabbits for up to six months; the interaction with surrounding bone, which is virtually devoid of bone marrow, was then assessed. The ceramics caused no adverse biological response. Tissue ingrowth into pores throughout the implant was seen in all three types and in both pore sizes of ceramic, but the density of the penetrating tissue was far less for calcium aluminate than for calcium hydroxyapatite or tricalcium phosphate. For each type of ceramic, the soft-tissue ingrowth was more dense with the larger pore size, and with a longer period of implantation. Bone ingrowth was not usually seen within the pores of any ceramic. There were no differences in the histological findings between the rats and the rabbits. The results demonstrate that it is possible to produce ceramic materials with a porous structure which allows ingrowth of tissue and biological fluids.

182 citations

Journal ArticleDOI
TL;DR: The properties of the various bone grafting materials currently available are highlighted and their efficacy in clinical practice is discussed.

169 citations