Automated identification of stratifying signatures in cellular subpopulations
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Cites methods from "Automated identification of stratif..."
...The algorithm is termedCluster Identification, Characterization, andRegression (Citrus) (Bruggner et al., 2014) and combines hierarchical clustering of cell events with machine learning approaches to identify statistically significant features between groups of samples or to build a predictive…...
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...The algorithm is termedCluster Identification, Characterization, andRegression (Citrus) (Bruggner et al., 2014) and combines hierarchical clustering of cell events with machine learning approaches to identify statistically significant features between groups of samples or to build a predictive model for a particular sample type (Bair and Tibshirani, 2004)....
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677 citations
653 citations
Cites methods from "Automated identification of stratif..."
...We therefore determined whether the statistical inference integrated into Citrus could, instead, be applied to Scaffold maps....
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...We then used the Significance Analysis of Microarrays framework to identify statistically significant features between the sample types (effective versus ineffective treatment groups) as in Citrus (Bair and Tibshirani, 2004; Bruggner et al., 2014)....
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...Another algorithm for mass cytometry analysis, Citrus (Bruggner et al., 2014), provides statistical comparisons between groups....
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...The results from Citrus, however, can be cumbersome to interpret....
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427 citations
References
40,785 citations
"Automated identification of stratif..." refers methods in this paper
...Accordingly, Citrus constructs classification models using the lassoregularized logistic regression and nearest shrunken centroid methods (21, 22)....
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7,400 citations
"Automated identification of stratif..." refers methods in this paper
...Alternatively, sparse regression models such as the group lasso (30) that explicitly account for correlated features could be incorporated into the Citrus workflow, thus eliminating a need to reconcile related cell subsets after regression....
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4,259 citations
2,954 citations
"Automated identification of stratif..." refers methods in this paper
...Accordingly, Citrus constructs classification models using the lassoregularized logistic regression and nearest shrunken centroid methods (21, 22)....
[...]
2,177 citations