Journal ArticleDOI
Autophagy and Alzheimer's Disease.
Reads0
Chats0
TLDR
The latest progress supporting the role for autophagy deficits in AD and the potential therapeutic effects of autophagic modulators in AD are summarized.Abstract:
Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in mammalian cells and is responsible for protein homeostasis and neuronal health. Several studies have shown that autophagy deficits occurred in early stage of Alzheimer's disease (AD). Autophagy plays an important role in generation and metabolism of β-amyloid (Aβ), assembling of tau and thus its malfunction may lead to the progress of AD. By considering the above evidences, autophagy may be a new target in developing drugs for AD. So far, a number of mammalian target of rapamycin (mTOR)-dependent and independent autophagy modulators have been identified to have positive effects in AD treatment. In this review, we summarized the latest progress supporting the role for autophagy deficits in AD and the potential therapeutic effects of autophagy modulators in AD.read more
Citations
More filters
Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg,Heide Knauer,Alexandra Schauer,Sabrina Büttner,Christoph Ruckenstuhl,Didac Carmona-Gutierrez,Julia Ring,Sabrina Schroeder,Christoph Magnes,Lucia Antonacci,Heike Fussi,Luiza Deszcz,Luiza Deszcz,Regina Hartl,Regina Hartl,Elisabeth Schraml,Alfredo Criollo,Evgenia Megalou,Daniela Weiskopf,Peter Laun,Gino Heeren,Michael Breitenbach,Beatrix Grubeck-Loebenstein,Eva Herker,Birthe Fahrenkrog,Kai-Uwe Fröhlich,Frank Sinner,Nektarios Tavernarakis,Nadège Minois,Nadège Minois,Nadège Minois,Guido Kroemer,Frank Madeo +32 more
TL;DR: Administration of spermidine markedly extended the lifespan of yeast, flies and worms, and human immune cells and inhibited oxidative stress in ageing mice, and found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.
Journal ArticleDOI
Homocysteine, B Vitamins, and Cognitive Impairment
TL;DR: Trials in high-risk subjects, which have taken into account the baseline B vitamin status, show a slowing of cognitive decline and of atrophy in critical brain regions, results that are consistent with modification of the Alzheimer's disease process.
Journal ArticleDOI
Hallmarks of Aging: An Autophagic Perspective
TL;DR: Recent papers showing the impact of autophagy on cell activity and age-associated diseases are discussed, highlighting the relevance of this process to the hallmarks of aging.
Journal ArticleDOI
Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process.
TL;DR: Evidence is discussed that atypical mitophagy and nonmitophagic pathways play central roles in mitochondrial quality control, functioning that was previously considered to be the primary domain of Mitophagy.
Journal ArticleDOI
Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases.
TL;DR: Mechanisms governing systemic and cellular iron homeostasis, and the related roles of ferritin and mitochondria are detailed, as are mechanisms explaining the negative regulation of ferroptosis.
References
More filters
Journal ArticleDOI
The role of autophagy during the early neonatal starvation period
Akiko Kuma,Masahiko Hatano,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Haruaki Nakaya,Tamotsu Yoshimori,Yoshinori Ohsumi,Takeshi Tokuhisa,Noboru Mizushima,Noboru Mizushima,Noboru Mizushima +11 more
TL;DR: The results suggest that the production of amino acids by autophagic degradation of ‘self’ proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
Journal ArticleDOI
In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
Noboru Mizushima,Akitsugu Yamamoto,Makoto Matsui,Makoto Matsui,Tamotsu Yoshimori,Yoshinori Ohsumi,Yoshinori Ohsumi +6 more
TL;DR: The results suggest that the regulation of autophagy is organ dependent and the role of Aut7/Apg8 is not restricted to the starvation response, and this transgenic mouse model is a useful tool to study mammalian autophagic regulation.
Journal ArticleDOI
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
TL;DR: The role of reactive oxygen species (ROS) as signaling molecules in starvation‐induced autophagy is described and a cysteine residue located near the HsAtg4 catalytic site is specified as a critical for this regulation.
Journal ArticleDOI
Autophagy and Aging
TL;DR: The probable cause and effect relationship between perturbed autophagy and aging is discussed, as well as possible molecular mechanisms that may mediate the anti-aging effects of Autophagy.
Journal ArticleDOI
The role of autophagy in neurodegenerative disease
TL;DR: An overview of the role of autophagy in neurodegenerative disease is provided, focusing particularly on less frequently considered lysosomal clearance mechanisms and their considerable impact on disease.
Related Papers (5)
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee,Ju-Hyun Lee,W. Haung Yu,W. Haung Yu,Asok Kumar,Asok Kumar,Sooyeon Lee,Sooyeon Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Corrinne M. Peterhoff,Devin M. Wolfe,Marta Martinez-Vicente,Ashish C. Massey,Guy Sovak,Yasuo Uchiyama,David Westaway,Ana Maria Cuervo,Ralph A. Nixon,Ralph A. Nixon +19 more