Autophagy induced by ischemic preconditioning is essential for cardioprotection.
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Cites background from "Autophagy induced by ischemic preco..."
...A dominant negative transgene of autophagy-related protein 5 abolished the IS reduction by IPC.(417)...
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Cites methods from "Autophagy induced by ischemic preco..."
...The isolated perfused rat heart model was previously described [28]....
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References
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"Autophagy induced by ischemic preco..." refers background in this paper
...To extend the potential significance of autophagy in cardioprotection beyond ischemic preconditioning, we also examined three structurally unrelated cardioprotective agents, which are as follows: UTP [29], diazoxide [30], and ranolazine [31]....
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971 citations
"Autophagy induced by ischemic preco..." refers background in this paper
...Although p62 accumulates in tissues in association with ubiquitinated protein aggregates when autophagy is chronically suppressed [26], protein levels of p62 can rise acutely in response to oxidative stress or other stimuli [25]....
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737 citations
"Autophagy induced by ischemic preco..." refers background in this paper
...IPC and pharmacologic agents have shown promise in animal studies, but many have failed in the clinical setting [46]....
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702 citations
"Autophagy induced by ischemic preco..." refers background in this paper
...The putative mitochondrial ATP-sensitive potassium channel (mitoKATP), production of nitric oxide, and ROS are also consistent features of IPC [5, 28]....
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