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Open AccessJournal ArticleDOI

Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.

Maximiliano G. Gutierrez, +5 more
- 17 Dec 2004 - 
- Vol. 119, Iss: 6, pp 753-766
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TLDR
It is demonstrated that autophagic pathways can overcome the trafficking block imposed by M. tuberculosis, which is a hormonally, developmentally, and immunologically regulated process, represents an underapp appreciated innate defense mechanism for control of intracellular pathogens.
About: 
This article is published in Cell.The article was published on 2004-12-17 and is currently open access. It has received 2108 citations till now. The article focuses on the topics: Autophagy & Phagosome maturation.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Autophagy: process and function

Noboru Mizushima
- 15 Nov 2007 - 
TL;DR: In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.
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Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, +12 more
- 15 Jun 2006 - 
TL;DR: It is found that mice lacking Atg7 specifically in the central nervous system showed behavioural defects, including abnormal limb-clasping reflexes and a reduction in coordinated movement, and died within 28 weeks of birth, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies.
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Mitochondrial Membrane Permeabilization in Cell Death

Guido Kroemer, +2 more
- 01 Jan 2007 - 
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
References
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Journal ArticleDOI

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukiko Kabeya, +13 more
- 01 Nov 2000 - 
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
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Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy

Beth Levine, +1 more
- 01 Apr 2004 - 
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Xiao Huan Liang, +6 more
- 09 Dec 1999 - 
TL;DR: It is shown that beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma, suggesting that decreased expression of Autophagy proteins may contribute to the development or progression of breast and other human malignancies.
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Global Burden of Tuberculosis: Estimated Incidence, Prevalence, and Mortality by Country

Christopher Dye, +4 more
- 18 Aug 1999 - 
TL;DR: The global burden of tuberculosis remains enormous, mainly because of poor control in Southeast Asia, sub-Saharan Africa, and eastern Europe, and because of high rates of M tuberculosis and HIV coinfection in some African countries.
Journal ArticleDOI

Immunology of tuberculosis.

JoAnne L. Flynn, +1 more
- 28 Nov 2003 - 
TL;DR: This review summarizes the current understanding of the host immune response, with emphasis on the roles of macrophages, T cells, and the cytokine/chemokine network in engendering protective immunity.
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Autophagy defends cells against invading group A Streptococcus.

Ichiro Nakagawa, +11 more
- 05 Nov 2004 - 

Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Sudha Singh, +4 more
- 08 Sep 2006 - 

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukiko Kabeya, +13 more
- 01 Nov 2000 - 

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Miguel A. Sanjuan, +10 more
- 20 Dec 2007 - 

Autophagy in immunity and inflammation

Beth Levine, +2 more
- 20 Jan 2011 -