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Journal ArticleDOI

Ayurgenomics and Modern Medicine.

30 Nov 2020-Medicina-lithuania (Multidisciplinary Digital Publishing Institute)-Vol. 56, Iss: 12, pp 661
TL;DR: The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health.
Abstract: Within the disciplines of modern medicine, P4 medicine is emerging as a new field which focuses on the whole patient. The development of Ayurgenomics could greatly enrich P4 medicine by providing a clear theoretical understanding of the whole patient and a practical application of ancient and modern preventative and therapeutic practices to improve mental and physical health. One of the most difficult challenges today is understanding the ancient concepts of Ayurveda in terms of modern science. To date, a number of researchers have attempted this task, of which one of the most successful outcomes is the creation of the new field of Ayurgenomics. Ayurgenomics integrates concepts in Ayurveda, such as Prakriti, with modern genetics research. It correlates the combination of three doshas, Vata, Pitta and Kapha, with the expression of specific genes and physiological characteristics. It also helps to interpret Ayurveda as an ancient science of epigenetics which assesses the current state of the doshas, and uses specific personalized diet and lifestyle recommendations to improve a patient's health. This review provides a current update of this emerging field.
Citations
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Journal ArticleDOI
TL;DR: Despite advances in modern medicine, contemporary society has experienced a series of epidemics and pandemics of noncommunicable, chronic diseases and communicable, infectious diseases as discussed by the authors, which has been referred to as pandemic epidemics.
Abstract: Despite advances in modern medicine, contemporary society has experienced a series of epidemics and pandemics of noncommunicable, chronic diseases and communicable, infectious diseases [...]

3 citations

Journal ArticleDOI
TL;DR: This work tries to understand prakriti’s use in personalized medicine, and how to integrate it with programs for drug development and discovery.
Abstract: Originating in ancient India, Ayurveda is an alternative medicinal approach that provides substantial evidence for a theoretical-level analysis of all aspects of life. Unlike modern medicine, Ayurveda is based upon tridoshas (Vata, pitta, and Kapha) and Prakriti. On the other hand, the research of all the genes involved at the proteomics, metabolomics, and transcriptome levels are referred to as genomics. Geoclimatic regions (deshanupatini), familial characteristics (kulanupatini), and ethnicity (jatiprasakta) have all been shown to affect phenotypic variability. The combination of genomics with Ayurveda known as ayurgenomics provided new insights into tridosha that may pave the way for precision medicine (personalized medicine). Through successful coordination of “omics,” Prakriti-based treatments can help change the existing situation in health care. Prakriti refers to an individual’s behavioral trait, which is established at the moment of birth and cannot be fully altered during one’s existence. Ayurvedic methodologies are based on three Prakriti aspects: aushadhi (medication), vihara (lifestyle), and ahara (diet). A foundation of Prakriti-based medicine, preventative medicine, and improvement of life quality with longevity can be accomplished through these ayurvedic characteristics. In this perspective, we try to understand prakriti’s use in personalized medicine, and how to integrate it with programs for drug development and discovery.

2 citations

Journal ArticleDOI
TL;DR: The novel concept of Ayurnutrigenomics is an innovative perception of nutrigenomic research for developing personalized functional foods and nutraceuticals suitable for one's genetic makeup with the help of Ayurveda.
Abstract: Ahara is one of the three pillars of life according to Ayurveda. Along with medicine, food plays a role in the prevention and mitigation of diseases. Compared to any drug, food is consumed in large quantity. Hence, research on its effect and interaction with the genome is highly relevant towards understanding diseases and their management. The epistemic perspective on health and nutrition in Ayurveda is different from that of biomedicine and modern nutrition. However, contemporary knowledge is reinventing and advancing several of these concepts in an era of systems biology and personalized medicine. Ayurgenomics presents a personalized approach in the predictive, preventive, and curative aspects of medicine. It is the study of interindividual variability due to genetic variability in humans for assessing diagnosis and prognosis of diseases, mainly based on the Prakriti (constitution type of person). In the emerging eld of Ayurnutrigenomics, based on the clinical assessment of an individual’s Prakriti the selection of suitable ahara, oushadha, and vihara are made. This Ayurveda-inspired concept of personalized nutrition is an innovative perception of nutrigenomic research for developing personalized functional foods and nutraceuticals suitable for one's genetic makeup with the help of Ayurveda. Trans-disciplinary research could be important for pushing the boundaries of food and health sciences and also for providing practical solutions for contemporary health conditions. Hence this novel concept of Ayurnutrigenomics and its emerging areas of research, may unfold future possibilities towards smart yet safe therapeutics.

1 citations

Journal ArticleDOI
TL;DR: Ayurveda has an abundant resource of botanical products containing diverse pharmaco-active ingredients and millennia of experience of clinical applications for health benefits, but there is a lack of evidence-based research to demonstrate its efficacy and potential as discussed by the authors .

1 citations

Journal ArticleDOI
TL;DR: In this paper, the authors examine neuroadaptability and how it affects health from the perspective of modern medicine and Ayurveda and examine the effect of these threats/challenges on individuals' health.
Abstract: In our increasingly stressed world, especially with the COVID-19 pandemic, the activation of the threat network in everyday situations can adversely affect our mental and physical health. Neurophysiological response to these threats/challenges depends on the type of challenge and the individual's neuroadaptability. Neuroadaptability is defined as the ability of the nervous system to alter responsiveness over time to reoccurring stimuli. Neuroadaptability differs from neuroplasticity, which is more inclusive and refers to the ability of the nervous system to change and learn from any experience. We examine neuroadaptability and how it affects health from the perspective of modern medicine and Ayurveda.
References
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Journal ArticleDOI
22 Oct 2004-Science
TL;DR: Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; the possibility that these differences may be reflected by multiparameter measurements of the blood is pursued.
Abstract: Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine

1,041 citations

Journal ArticleDOI
TL;DR: In this review, systems biology is defined, the current capabilities of proteomics are discussed and some of the necessary milestones for moving systems biology and proteomics into mainstream health care are highlighted.
Abstract: The emergence of systems biology is bringing forth a new set of challenges for advancing science and technology. Defining ways of studying biological systems on a global level, integrating large and disparate data types, and dealing with the infrastructural changes necessary to carry out systems biology, are just a few of the extraordinary tasks of this growing discipline. Despite these challenges, the impact of systems biology will be far-reaching, and significant progress has already been made. Moving forward, the issue of how to use systems biology to improve the health of individuals must be a priority. It is becoming increasingly apparent that the field of systems biology and one of its important disciplines, proteomics, will have a major role in creating a predictive, preventative, and personalized approach to medicine. In this review, we define systems biology, discuss the current capabilities of proteomics and highlight some of the necessary milestones for moving systems biology and proteomics into mainstream health care.

683 citations

Journal ArticleDOI
TL;DR: Working together in digitally powered familial and affinity networks, consumers will be able to reduce the incidence of the complex chronic diseases that currently account for 75% of disease-care costs in the USA.
Abstract: Ten years ago, the proposition that healthcare is evolving from reactive disease care to care that is predictive, preventive, personalized and participatory was regarded as highly speculative. Today, the core elements of that vision are widely accepted and have been articulated in a series of recent reports by the US Institute of Medicine. Systems approaches to biology and medicine are now beginning to provide patients, consumers and physicians with personalized information about each individual's unique health experience of both health and disease at the molecular, cellular and organ levels. This information will make disease care radically more cost effective by personalizing care to each person's unique biology and by treating the causes rather than the symptoms of disease. It will also provide the basis for concrete action by consumers to improve their health as they observe the impact of lifestyle decisions. Working together in digitally powered familial and affinity networks, consumers will be able to reduce the incidence of the complex chronic diseases that currently account for 75% of disease-care costs in the USA.

407 citations

Journal ArticleDOI
TL;DR: It is predicted that systems approaches will empower the transition from conventional reactive medical practice to a more proactive P4 medicine focused on wellness, and will reverse the escalating costs of drug development an will have enormous social and economic benefits.
Abstract: Personalized medicine is a term for a revolution in medicine that envisions the individual patient as the central focus of healthcare in the future. The term "personalized medicine", however, fails to reflect the enormous dimensionality of this new medicine that will be predictive, preventive, personalized, and participatory-a vision of medicine we have termed P4 medicine. This reflects a paradigm change in how medicine will be practiced that is revolutionary rather than evolutionary. P4 medicine arises from the confluence of a systems approach to medicine and from the digitalization of medicine that creates the large data sets necessary to deal with the complexities of disease. We predict that systems approaches will empower the transition from conventional reactive medical practice to a more proactive P4 medicine focused on wellness, and will reverse the escalating costs of drug development an will have enormous social and economic benefits. Our vision for P4 medicine in 10 years is that each patient will be associated with a virtual data cloud of billions of data points and that we will have the information technology for healthcare to reduce this enormous data dimensionality to simple hypotheses about health and/or disease for each individual. These data will be multi-scale across all levels of biological organization and extremely heterogeneous in type - this enormous amount of data represents a striking signal-to-noise (S/N) challenge. The key to dealing with this S/N challenge is to take a "holistic systems approach" to disease as we will discuss in this article.

211 citations

Journal ArticleDOI
TL;DR: It is hypothesized that there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda and this may provide an appropriate means of classifying phenotypes to be considered collectively for genotyping.
Abstract: Background: Correlating phenotypes with genotypes remains the major postgenomic challenge. Attempts to correlate phenotype characteristics associated with ethnicity, geographical divisions, or diseases to genotypes have had limited success. This means that current approaches for identifying phenotypes associated with haplotypes may be inadequate. Objectives: We hypothesize that a human phenome based on Ayurveda could provide an appropriate approach. Specifically, there could be a genetic basis for the three major constitutions (Prakriti) described in Ayurveda. The Prakriti classification is based on differences in physical, physiological, and psychologics characteristics and is independent of racial, ethnic, or geographical considerations. It may provide an appropriate means of classifying phenotypes to be considered collectively for genotyping. Design: As a pilot study to test the hypothesis, we evaluated 76 subjects both for their Prakriti and human leucocyte antigen (HLA) DRB1 types. The genomic DNA wa...

157 citations


"Ayurgenomics and Modern Medicine." refers result in this paper

  • ...Furthermore, HLA DRB1*10 had higher allele frequency in the Kapha type compared to the Pitta and Vata types [2]....

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