β‐glucan recognition by the innate immune system
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TLDR
This review explores what is currently known about β‐glucan recognition and how this recognition stimulates immune responses, and special emphasis is placed on Dectin‐1, as the authors know the most about how this key β‐ glucan receptor translates recognition into intracellular signaling, stimulates cellular responses,and participates in orchestrating the adaptive immune response.Abstract:
Beta-glucans are recognized by the innate immune system. This recognition plays important roles in host defense and presents specific opportunities for clinical modulation of the host immune response. Neutrophils, macrophages, and dendritic cells among others express several receptors capable of recognizing beta-glucan in its various forms. This review explores what is currently known about beta-glucan recognition and how this recognition stimulates immune responses. Special emphasis is placed on Dectin-1, as we know the most about how this key beta-glucan receptor translates recognition into intracellular signaling, stimulates cellular responses, and participates in orchestrating the adaptive immune response.read more
Citations
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Activation of the innate immune receptor Dectin-1 upon formation of a /`phagocytic synapse/'
Helen S. Goodridge,Christopher N. Reyes,Courtney A. Becker,Tamiko R. Katsumoto,Jun Ma,Andrea J. Wolf,Nandita Bose,Anissa S.H. Chan,Andrew S. Magee,Michael E. Danielson,Arthur Weiss,John P. Vasilakos,David M. Underhill,David M. Underhill +13 more
TL;DR: The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required.
Journal ArticleDOI
Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease
TL;DR: Recent advances in the understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune responses have led to an expanded appreciation for functions of these cells beyond immunity, including maintenance of physiologic homeostasis and tissue repair.
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Fish immune system and its nutritional modulation for preventive health care
TL;DR: The role of dietary nutrients or additives on the functions of the immune system in fish has been investigated since the 1980s and more convincing evidences should be gathered before they are classified as ‘functional ingredients’.
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Fungi and allergic lower respiratory tract diseases
Alan P. Knutsen,Robert K. Bush,Jeffrey G. Demain,David W. Denning,Anupma Dixit,Abbie Fairs,Paul A. Greenberger,Barbara Kariuki,Hirohito Kita,Viswanath P. Kurup,Richard B. Moss,Robert Niven,Catherine H. Pashley,Raymond G. Slavin,Hari M. Vijay,Andrew J. Wardlaw +15 more
TL;DR: The term severe asthma associated with fungal sensitization (SAFS) has been coined to illustrate the high rate of fungal sensitivity in patients with persistent severe asthma and improvement with antifungal treatment.
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Asthma and allergic inflammation
TL;DR: The similarities of these responses with mucosal responses to parasitic intestinal worms may reveal pathways relevant to the perplexing rise of these chronic inflammatory disorders.
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Dectin-1 Mediates the Biological Effects of β-Glucans
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