β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments.
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...For instance, β1 integrins can assemble adhesion complex without myosin-driven contractility and exhibit fast translocation in FAs, whereas β3 integrins are stationary in FAs and quickly internalized when force is released (Rossier et al., 2012; Schiller et al., 2013; Yu et al., 2015)....
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...It is also important to note that there is no simple correlation between the adhesion size and the magnitude of the transmitted force (Oakes et al., 2012; Schiller et al., 2013), Figure 1....
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...…also important to note that there is no simple correlation between the adhesion size and the magnitude of the transmitted force (Oakes et al., 2012; Schiller et al., 2013), Integrin-mediated mechanotransduction • Sun et al. 447 as small NAs may also transmit forces that are high enough to drive…...
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...Both RhoA downstream pathways are required for optimal cellular tension and rigidity sensing (Schiller et al., 2013)....
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