Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation
Mariann I. Lassenius,Kirsi H. Pietiläinen,Kati Kaartinen,Pirkko J. Pussinen,Jaana Syrjänen,Carol Forsblom,Ilkka Pörsti,Aila Rissanen,Jaakko Kaprio,Jukka Mustonen,Per-Henrik Groop,Markku Lehto +11 more
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TLDR
In this paper, the authors investigated whether bacterial lipopolysaccharide (LPS) activity in human serum is associated with the components of the metabolic syndrome (MetS) in type 1 diabetic patients with various degrees of kidney disease and patients with IgA glomerulonephritis (IgAGN).Abstract:
OBJECTIVE To investigate whether bacterial lipopolysaccharide (LPS) activity in human serum is associated with the components of the metabolic syndrome (MetS) in type 1 diabetic patients with various degrees of kidney disease and patients with IgA glomerulonephritis (IgAGN) RESEARCH DESIGN AND METHODS Serum LPS activity was determined with the Limulus Amoebocyte Lysate chromogenic end point assay in type 1 diabetic patients with a normal albumin excretion rate ( n = 587), microalbuminuria ( n = 144), macroalbuminuria ( n = 173); patients with IgAGN ( n = 98); and in nondiabetic control subjects ( n = 345) The relationships of the LPS/HDL ratio and MetS-associated variables were evaluated with Pearson correlation RESULTS The MetS was more prevalent in type 1 diabetic patients (48%) than in patients with IgAGN (15%) Diabetic patients with macroalbuminuria had a significantly higher serum LPS/HDL ratio than patients with IgAGN In the normoalbuminuric type 1 diabetic group, patients in the highest LPS/HDL quartile were diagnosed as having the MetS three times more frequently than patients in the lowest quartile (69 vs 22%; P CONCLUSIONS High serum LPS activity is strongly associated with the components of the MetS Diabetic patients with kidney disease seem to be more susceptible to metabolic endotoxemia than patients with IgAGN Bacterial endotoxins may thus play an important role in the development of the metabolic and vascular abnormalities commonly seen in obesity and diabetes-related diseasesread more
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Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani,Jacques Amar,Miguel A. Iglesias,Marjorie Poggi,Claude Knauf,Delphine Bastelica,Audrey M. Neyrinck,Francesca Fava,Kieran Tuohy,Chantal Chabo,Aurélie Waget,Evelyne Delmée,Béatrice Cousin,Thierry Sulpice,Bernard Chamontin,Jean Ferrières,Jean-François Tanti,Glenn R. Gibson,Louis Casteilla,Nathalie M. Delzenne,Marie-Christine Alessi,Rémy Burcelin +21 more
TL;DR: It is concluded that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity and lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases.
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The role of inflammatory cytokines in diabetes and its complications.
George L. King,George L. King +1 more
TL;DR: Although the precise role of inflammation in the development of diabetic microvascular diseases is still unclear, it is likely that inflammation induced by diabetes and insulin resistance can accelerate atherosclerosis in patients with diabetes.
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