Bacterial Translocation Associates With Aggression in Schizophrenia Inpatients.
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TLDR
In this paper, the authors evaluated the associations among aggression, inflammation, and bacterial translocation (BT) in aggression-affected schizophrenia (ScZ) inpatients with 2 weeks of antipsychotics discontinuation.Abstract:
Objective: Accumulating evidence indicates that inflammation abnormalities may contribute to aggression behaviors in psychotic patients, however, the possible sources of inflammation remain elusive. We aimed to evaluate the associations among aggression, inflammation, and bacterial translocation (BT) in aggression-affected schizophrenia (ScZ) inpatients with 2 weeks of antipsychotics discontinuation.
Methods: Serum specimens collected from 112 aggression and 112 non-aggression individuals with ScZ and 56 healthy adults were used for quantifications of inflammation- or BT-related biomarkers. Aggression severity was assessed by Modified Overt Aggression Scale (MOAS).
Results: Proinflammation phenotype dominated and leaky gut-induced BT occurred only in cases with ScZ with a history of aggression, and the MOAS score positively related to levels of C-reactive protein, interleukin (IL)-6, IL-1β, and tumor necrosis factor-α. Furthermore, serum levels of BT-derived lipopolysaccharide (LPS), as well as LPS-responded soluble CD14, were not only positively correlated with levels of above proinflammation mediators but also the total MOAS score and subscore for aggression against objects or others.
Conclusion: Our results collectively demonstrate the presence of leaky gut and further correlate BT-derived LPS and soluble CD14 to onset or severity of aggression possibly by driving proinflammation response in inpatients with ScZ, which indicates that BT may be a novel anti-inflammation therapeutic target for aggression prophylaxis.read more
Citations
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Altered gut microbiota and its metabolites correlate with plasma cytokines in schizophrenia inpatients with aggression
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References
More filters
Journal ArticleDOI
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
TL;DR: Similar effect sizes in AR and FEP suggest that the association between cytokine abnormalities and acute exacerbations of schizophrenia is independent of antipsychotic medications.
Journal ArticleDOI
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.
Fiona J Charlson,Fiona J Charlson,Fiona J Charlson,Alize J. Ferrari,Alize J. Ferrari,Alize J. Ferrari,Damian Santomauro,Damian Santomauro,Damian Santomauro,Sandra Diminic,Sandra Diminic,Emily Stockings,James Scott,James Scott,James Scott,John J. McGrath,John J. McGrath,John J. McGrath,Harvey Whiteford,Harvey Whiteford,Harvey Whiteford +20 more
TL;DR: Although schizophrenia is a low prevalence disorder, the burden of disease is substantial, and modeling suggests that significant population growth and aging has led to a large and increasing disease burden attributable to schizophrenia, particularly for middle income countries.
Journal ArticleDOI
Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation
Anastasia I. Petra,Smaro Panagiotidou,Erifili Hatziagelaki,Julia M. Stewart,Pio Conti,Theoharis C. Theoharides +5 more
TL;DR: Recognition of the relationship between the MGB axis and the neuroimmune systems provides a novel approach for better understanding and management of these disorders.
Journal ArticleDOI
Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia
Jari Tiihonen,Ellenor Mittendorfer-Rutz,Maila Majak,Juha Mehtälä,Fabian Hoti,Erik Jedenius,Dana Enkusson,Amy Leval,Jan Sermon,Antti Tanskanen,Heidi Taipale +10 more
TL;DR: Clozapine and long-acting injectable antipsychotic medications were the pharmacologic treatments with the highest rates of prevention of relapse in schizophrenia.
Journal ArticleDOI
The role of inflammation in schizophrenia
TL;DR: Anti-inflammatory effects of antipsychotics, therapeutic effects of anti-inflammtory compounds, genetic, biochemical, and immunological findings point to a major role of inflammation in schizophrenia.