Bariatric Surgery and the Risk of Cancer in a Large Multisite Cohort
Daniel P. Schauer,Heather Spencer Feigelson,Corinna Koebnick,Bette J. Caan,Sheila Weinmann,Anthony C. Leonard,J. David Powers,Panduranga R. Yenumula,David Arterburn +8 more
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TLDR
In this large, multisite cohort of patients with severe obesity, bariatric surgery was associated with a lower risk of incident cancer, particularly obesity-associated cancers, such as postmenopausal breast cancer, endometrial cancer, and colon cancer.Abstract:
Objective:To determine whether bariatric surgery is associated with a lower risk of cancer.Background:Obesity is strongly associated with many types of cancer. Few studies have examined the relationship between bariatric surgery and cancer risk.Methods:We conducted a retrospective cohort study of paread more
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Gut microbiota in colorectal cancer: mechanisms of action and clinical applications
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TL;DR: The role of microorganisms in colorectal carcinogenesis, and the potential clinical translation of the gut microbiota as a biomarker for CRC diagnosis and prognosis are described, and as an approach for disease prevention and to improve therapy are described.
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Benefits and Risks of Bariatric Surgery in Adults: A Review.
TL;DR: All patients with severe obesity-and especially those with type 2 diabetes-should be engaged in a shared decision-making conversation about the risks and benefits of surgery compared with continuing usual medical and lifestyle treatment, and the decision about surgery should be driven primarily by informed patient preferences.
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The obese adipose tissue microenvironment in cancer development and progression
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Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery.
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TL;DR: Experts from the Diabetes Surgery Summit consensus conference series provide guidance for the management of patients while surgery is delayed and for postoperative surveillance and offer a strategy to prioritise bariatric and metabolic surgery candidates on the basis of the diseases that are most likely to be ameliorated postoperatively.
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Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications
TL;DR: This review describes the complex relationship between obesity, diabetes and cancer focusing on epidemiologic and pathophysiologic evidence, also reviewing the role of anti-hyperglycemic agents, novel research approaches such as Mendelian Randomization as well as methodologic limitations of existing research.
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