Baseline MRI predictors of conversion from MCI to probable AD in the ADNI cohort.
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Cites background from "Baseline MRI predictors of conversi..."
...Reproduced with permission from Ref [114]....
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...Images are in on a specially constructed average brain template created from the subjects m Ref [133]....
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...Table 6 Associations between imaging, clinical, and CSF biomarkers (correlation coefficients) CSF biomarker correlates Imaging or clinical biomarker N Clinical group Ab242 t-tau p-tau181p t-tau/Ab242 FDG-PET composite ROI Mean cortical PiB SUVR Reference Hippocampal volume (L/R) 388 Pooled sample 0.11*/0.17y 20.17y/0.21z 20.17y/20.23z 20.17y/20.21z 20.24*/20.23* [151] Mean cortical PiB SUVR 55 Pooled sample 20.73z 20.42x 0.49z 0.28* [34] FDG-PET composite ROI 0.33y 0.24 (P ¼ .08) 0.34y MMSE NS 0.26 (P ¼ .055) 0.28* 0.63z NS Ab242 0.38y APOE 34 77 CN 20.50z NS NS [146] 119 MCI 20.49z 0.39z 0.34y 54 AD 20.53z NS NS BMI 112 CN 0.19z 20.20z 20.43y [280] 193 MCI NS 20.17* 20.32z 100 AD NS NS NS Abbreviations: NS, not significant; SUVR, standard uptake value ratio....
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...The studies of Morra et al [124], Wolz et al [64], Hua et al [112], and Risacher et al [115] all found that carriers of the APOE 34 allele had higher rates of hippocampal atrophy than noncarriers....
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...They ygdala; Hp, hippocampus; V, ventricles; iLV, inferior lateral ventricles; Cd, ssion from Ref [122]....
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Cites background from "Baseline MRI predictors of conversi..."
...Neuroimaging has played a critical role in identifying the topography of dysfunctional brain areas, showing both morphological and volumetric structural changes, particularly in the entorhinal cortex and hippocampus, predating the cognitive symptoms and tracking with disease severity.(4,5) The structural abnormalities in AD are tightly coupled to functional disturbances....
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639 citations
Cites background from "Baseline MRI predictors of conversi..."
...An intermediate rate of atrophy is found in people with mild cognitive impairment (MCI) [6,7,8,9,10,11]....
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502 citations
References
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"Baseline MRI predictors of conversi..." refers background in this paper
...As expected, neuropsychological test scores (MMSE [66, 67], Clinical Dementia Rating (CDR) [68], and the Functional Assessment Questionnaire (FAQ) [69]) varied significantly between groups (p<0....
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"Baseline MRI predictors of conversi..." refers methods in this paper
...Automated Parcellation: VOIs, including bilateral hippocampi and amygdalar nuclei, were extracted using FreeSurfer V4 [56, 59-62]....
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8,255 citations
"Baseline MRI predictors of conversi..." refers background in this paper
...Patients with MCI, specifically those with primary memory deficits or “amnestic MCI”, have a significantly higher likelihood to progress to probable AD, with a conversion rate of 10-15% per year [4]....
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