Journal ArticleDOI
Benzimidazole: a medicinally important heterocyclic moiety
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TLDR
Researchers have synthesized variety of benzimidazole derivatives and screened them for their various biological activities, viz., anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimycobacterial, antihypertensive, pro-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagULant, antioxidant as well antidiabetic activities.Abstract:
Benzimidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. Moreover, benzimidazole derivatives are structural isosters of naturally occurring nucleotides, which allows them to interact easily with the biopolymers of the living system. This created interest in researchers who have synthesized variety of benzimidazole derivatives and screened them for their various biological activities, viz., anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimycobacterial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant as well antidiabetic activities.read more
Citations
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Journal ArticleDOI
The therapeutic journey of benzimidazoles: a review.
Yogita Bansal,Om Silakari +1 more
TL;DR: In the present review, various derivatives of benzimidazole with different pharmacological activities are described on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimdazole derived compounds for each activity.
Journal ArticleDOI
A versatile approach to Ullmann C-N couplings at room temperature: new families of nucleophiles and electrophiles for photoinduced, copper-catalyzed processes.
Daniel T. Ziegler,Junwon Choi,José María Muñoz-Molina,Alex C. Bissember,Jonas C. Peters,Gregory C. Fu +5 more
TL;DR: The use of light to facilitate copper-catalyzed cross-couplings of nitrogen nucleophiles can enable C-N bond formation to occur under unusually mild conditions.
Journal ArticleDOI
Design, synthesis and biological evaluation of 1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents.
TL;DR: A series of forty different pyrazole containing benzimidazole hybrids have been designed, synthesized and evaluated for their potential anti-proliferative activity against three human tumor cell lines - lung, breast, and cervical.
Journal ArticleDOI
Benzimidazole Derivatives: Selective Fluorescent Chemosensors for the Picogram Detection of Picric Acid
Jin-Feng Xiong,Jianxiao Li,Guang-Zhen Mo,Jing-Pei Huo,Jin-Yan Liu,Xiaoyun Chen,Zhao-Yang Wang,Zhao-Yang Wang +7 more
TL;DR: Among 16 obtained compounds, compound 4g has the best capability for detection of picric acid (PA), having good selectivity and high sensitivity.
Journal ArticleDOI
Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole
TL;DR: The bioactive evaluation showed that 3,5-bis(trifluoromethyl)phenyl benzimidazoles gave comparable or even stronger antibacterial and antifungal efficiency in comparison with reference drugs Chloromycin, Norfloxacin and Fluconazole.
References
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Journal ArticleDOI
Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles.
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Journal ArticleDOI
Synthesis and Evaluation of Anticancer Benzoxazoles and Benzimidazoles Related to UK-1
TL;DR: Results support a role of Mg(2+) ion binding in the selective cytotoxicity of UK-1 and provide a minimal pharmacophore for the select cytotoxic activity of the natural product.
Journal ArticleDOI
Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species.
TL;DR: New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids, and cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values similar to that of fluconazole.
Journal ArticleDOI
2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2
Mario A. Pagano,Flavio Meggio,Maria Ruzzene,Mariola Andrzejewska,Zygmunt Kazimierczuk,Lorenzo A. Pinna +5 more
TL;DR: A novel compound, 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole (DMAT), is described, which is superior to the commonly used specific CK2 inhibitor 4, 5, 6, 7-t Petrabromobenzotriazoles (TBB) in several respects and is the first choice CK2 inhibitors for in vivo studies available to date.
Journal ArticleDOI
Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles
Kristina Starčević,Marijeta Kralj,Katja Ester,Ivan Sabol,Magdalena Grce,Krešimir Pavelić,Grace Karminski-Zamola +6 more
TL;DR: Interestingly, all compounds show noticeable selectivity toward breast cancer cell line MCF-7, and the most distinct and selective antiviral activity toward coxsackieviruses and echoviruses was observed with compounds having pyridine ring at C-2.
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