Beryllium disease: The relation of pulmonary pathology to clinical course and prognosis based on a study of 130 cases from the U.S. Beryllium Case Registry
TL;DR: A distinct relation between the intensity of interstitial cellular infiltration and prognosis is suggested and may provide additional insight into the clinical behavior of patients presenting with a histological picture resembling sarcoidosis.
About: This article is published in Human Pathology.The article was published on 1970-03-01. It has received 146 citations till now. The article focuses on the topics: Berylliosis.
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05 Nov 2009
TL;DR: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此第一印象中拟诊 结核5例,为此应引起临床对本 病诊
Abstract: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此病误诊的文献,误诊率高达63.2%,当然有误诊就会有误治,如孙永昌等~([2])报道26例结节病在影像学检查诊断的第一印象中拟诊结核5例,其中就有2例完成规范的抗结核治疗,为此应引起临床对本病诊治的重视。
1,821 citations
TL;DR: In this paper, the authors characterized the clinical, radiographic, physiologic, and pathologic findings of a unique idiopathic pleuroparenchymal fibroelastosis.
273 citations
TL;DR: Pneumoconiosis may be classified as either fibrotic or nonfibrotic, according to the presence or absence of fibrosis, and the presence of asbestos bodies in histopathologic specimens is specific for the diagnosis of asbestosis.
Abstract: Pneumoconiosis may be classified as either fibrotic or nonfibrotic, according to the presence or absence of fibrosis. Silicosis, coal worker pneumoconiosis, asbestosis, berylliosis, and talcosis are examples of fibrotic pneumoconiosis. Siderosis, stannosis, and baritosis are nonfibrotic forms of pneumoconiosis that result from inhalation of iron oxide, tin oxide, and barium sulfate particles, respectively. In an individual who has a history of exposure to silica or coal dust, a finding of nodular or reticulonodular lesions at chest radiography or small nodules with a perilymphatic distribution at thin-section computed tomography (CT), with or without eggshell calcifications, is suggestive of silicosis or coal worker pneumoconiosis. Magnetic resonance imaging is helpful for distinguishing between progressive massive fibrosis and lung cancer. CT and histopathologic findings in asbestosis are similar to those in idiopathic pulmonary fibrosis, but the presence of asbestos bodies in histopathologic specimens is specific for the diagnosis of asbestosis. Giant cell interstitial pneumonia due to exposure to hard metals is classified as a fibrotic form of pneumoconiosis and appears on CT images as mixed ground-glass opacities and reticulation. Berylliosis simulates pulmonary sarcoidosis on CT images. CT findings in talcosis include small centrilobular and subpleural nodules or heterogeneous conglomerate masses that contain foci of high attenuation indicating talc deposition. Siderosis is nonfibrotic and is indicated by a CT finding of poorly defined centrilobular nodules or ground-glass opacities.
258 citations
TL;DR: Bronchoalveolar lavage has emerged as a useful technique for the study of pulmonary interstitial disorders and has an established role in the diagnosis of opportunistic infections in the immunocompromised patient.
Abstract: Bronchoalveolar lavage has emerged as a useful technique for the study of pulmonary interstitial disorders. Several types of information are provided by the evaluation of lavage fluid. First, the identification of cellular constituents helps to separate inflammatory processes in which lymphocytes predominate (for example, sarcoidosis, hypersensitivity pneumonitis, and berylliosis) from those in which neutrophils or macrophages predominate (for example, idiopathic pulmonary fibrosis and histiocytosis X). Second, the cells removed during lavage can be studied for their immune properties and function; tested with specific antigens, in diseases such as berylliosis and hypersensitivity pneumonitis; and examined for the presence of unique surface antigens with monoclonal antibodies (for example, histiocytosis X). Third, in conjunction with scanning electron microscopy and electron probe analysis, lavage makes possible the identification of inorganic particles in alveolar macrophages of patients with pneumoconiotic lung disease. Finally, although lavage is still an investigative procedure for most pulmonary disorders, it has an established role in the diagnosis of opportunistic infections in the immunocompromised patient.
230 citations
TL;DR: The data suggest that the expansion of fibroblast numbers within theAlveolar structures in interstitial lung disorders may result, in part, from the release of AMDGF by alveolar macrophages stimulated in vivo.
Abstract: Interstitial lung disorders are characterized both by a chronic inflammation of the lower respiratory tract that includes increased numbers of activated alveolar macrophages and by increased numbers of fibroblasts within the alveolar wall. Since alveolar macrophages from normal individuals can be activated to release a growth factor for lung fibroblasts (alveolar macrophage-derived growth factor [AMDGF]), we hypothesized that the activated alveolar macrophages within the lower respiratory tract of patients with fibrotic lung disorders might be spontaneously releasing AMDGF. To evaluate this hypothesis, alveolar macrophages (suspension culture, 4 h, 37 degrees) from 65 patients with interstitial lung disorders and 30 control subjects were examined for the spontaneous release of fibroblast growth-promoting activity, with human lung fibroblasts as the target. Whereas none of the controls had macrophages spontaneously releasing a growth-promoting activity for fibroblasts, 82% of the patients with interstitial lung disease had alveolar macrophages that were spontaneously releasing a growth-promoting activity for fibroblasts. In common with AMDGF, the fibroblast growth-promoting activity released by these macrophages eluted from DEAE cellulose at 270 mM NaCl, had a partition coefficient of 0.3 by gel filtration on Sephadex G-50, was distinct from other characterized growth factors, and acted as a progression factor for fibroblast replication in a serum-free complementation test. These data suggest that the expansion of fibroblast numbers within the alveolar structures in interstitial lung disorders may result, in part, from the release of AMDGF by alveolar macrophages stimulated in vivo.
209 citations
References
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Book•
01 Mar 1985
TL;DR: This book discusses the anatomy of the lung, pulmonary vessels and lymphatics, and the pneumoconioses and other occupational lung diseases.
Abstract: Volume 1: Preface. Embryology of the lung. The anatomy of the lung. Congenital abnormalities of the lung, pulmonary vessels and lymphatics. Diseases of the bronchial tree. The bacterial pneumonias. Pneumonias due to rickettsiae, chlamydiae, viruses and mycoplasma. Chronic infective pneumonias. The pulmonary mycotic diseases. Lung abscesses. Pulmonary parasitic diseases. The pneumoconioses and other occupational lung diseases. Radiation injuries to the lung and lipoid pneumonia. Collapse, bronchial obstruction and its sequelae, shock lung and foreign bodies in the lung. Emphysema. Volume 2: Pulmonary thrombosis, fibrin thrombosis, pulmonary embolism and infarction. Chronic pulmonary hypertension. Pulmonary oedema and its complications and the effects of some toxic gases and substances on the lung. Degenerative and metabolic disorders of the lung. Pulmonary diseases of uncertain aetiology. Carcinoma of the lung. Rare pulmonary tumours. Pulmonary reticuloses. Hamartomas, blastoma and teratoma of the lung. Secondary tumours in the lung. An appendix of technical methods used in the study of lung pathology. References. Index.
709 citations
TL;DR: A large number of the available statistics on incidence are based on retrospective analysis and do not represent a clear picture of the prevalence of pulmonary embolism in men.
Abstract: RECOGNITION of the magnitude of the problem of pulmonary embolism in man requires reliable data concerning its incidence. Unfortunately, most of the available statistics on incidence are based on r...
257 citations
TL;DR: Can those cases in which neither autopsy nor lung biopsy was performed really be "proved" and "valid" beryllium disease?
163 citations
TL;DR: Individual hypersensitivity to molds or to their products seemed to be a decisive factor in a given exposure induced the disease in some persons while leaving others unaffected.
Abstract: Farmer's lung is a potentially serious and crippling disease that results from handling a variety of dusty, moldy organic materials. The symptoms are shortness of breath, cough, fever, chills, weight loss, and hemoptysis. This condition differs from silo filler's disease in both causation and symptoms. The roentgenographic findings are those of interstitial pneumonitis. Biopsy of the lung reveals a granulomatous interstitial pneumonitis with epithelioid and giant cells. This report is based on 39 cases. Lung biopsies were done in eight, and two cases are described in detail. Repeated exposure was followed by recurrence. No causative organism was found. A given exposure induced the disease in some persons while leaving others unaffected. Individual hypersensitivity to molds or to their products seemed to be a decisive factor. Antibiotic therapy is not primarily indicated. The essential treatment is for the patient to avoid repetition of the exposure.
160 citations