Beyond TGFβ: roles of other TGFβ superfamily members in cancer
Reads0
Chats0
TLDR
It is now becoming apparent that deregulated signalling by many of the other TGFβ superfamily members also has crucial roles in both the development of tumours and metastasis, and these signalling pathways are emerging as plausible therapeutic targets.Abstract:
Much of the focus on the transforming growth factor-β (TGFβ) superfamily in cancer has revolved around the TGFβ ligands themselves. However, it is now becoming apparent that deregulated signalling by many of the other superfamily members also has crucial roles in both the development of tumours and metastasis. Furthermore, these signalling pathways are emerging as plausible therapeutic targets. Their roles in tumorigenesis frequently reflect their function in embryonic development or in adult tissue homeostasis, and their influence extends beyond the tumours themselves, to the tumour microenvironment and more widely to complications of cancer such as cachexia and bone loss.read more
Citations
More filters
Functional genomics reveals a bmp driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming (oral presentation)
TL;DR: In this article, the authors explored the molecular mechanisms underlying the reprogramming process by exploiting a secondary mouse embryonic fibroblast model that forms iPSCs with high efficiency upon inducible expression of Oct4, Klf4, c-Myc, and Sox2.
Journal ArticleDOI
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Philip Gotwals,Scott Cameron,Daniela Cipolletta,Viviana Cremasco,Adam S. Crystal,Becker Hewes,Britta Mueller,Sonia Quaratino,Catherine Anne Sabatos-Peyton,Lilli Petruzzelli,Jeffrey A. Engelman,Glenn Dranoff +11 more
TL;DR: New insights into the effects of targeted therapies, along with conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical response in patients.
Journal ArticleDOI
Targeting TGF-β Signaling in Cancer.
TL;DR: The rationale for targeting TGF-β signaling in cancer is reviewed, the clinical status of pharmacological inhibitors are summarized, and the direct effects of TGF -β signaling blockade on tumor and stromal cells are discussed.
Journal ArticleDOI
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
Mübeccel Akdis,Alar Aab,Can Altunbulakli,Kursat A Azkur,Rita Costa,Reto Crameri,Su Duan,Thomas Eiwegger,Andrzej Eljaszewicz,Ruth Ferstl,Remo Frei,Mattia Garbani,Anna Głobińska,Lena Hess,Carly Huitema,Terufumi Kubo,Zsolt István Komlósi,Patricia Konieczna,Nóra Kovács,Umut Can Kucuksezer,Norbert Meyer,Hideaki Morita,Judith Olzhausen,Liam O'Mahony,Marija Pezer,Moira Prati,Ana Rebane,Claudio Rhyner,Arturo Rinaldi,Milena Sokolowska,Barbara Stanic,Kazunari Sugita,Angela Treis,Willem van de Veen,Kerstin Wanke,Marcin Wawrzyniak,Paulina Wawrzyniak,Oliver F. Wirz,Josefina Zakzuk,Cezmi A. Akdis +39 more
TL;DR: Recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons are reviewed and their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases are discussed.
Journal ArticleDOI
Targeting the TGFβ pathway for cancer therapy
Cindy Neuzillet,Annemilaï Tijeras-Raballand,Romain Cohen,Jérôme Cros,Sandrine Faivre,Eric Raymond,Armand de Gramont +6 more
TL;DR: The preclinical and clinical results of pharmacological strategies to target the TGFβ pathway and its deregulation in cancer, at the cancer cell and microenvironment levels are described, with a highlight on the effects on tumor microenvironment.
References
More filters
Journal ArticleDOI
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Yigong Shi,Joan Massagué +1 more
TL;DR: Current understanding on the mechanisms of TGF-β signaling from cell membrane to the nucleus is presented and the transcriptional regulation of target gene expression is reviewed.
Journal ArticleDOI
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
TL;DR: Owing to the importance of these tumour-associated phenotypes in metastasis and cancer-related mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients.
Journal ArticleDOI
TGFβ signalling in context.
TL;DR: The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed and the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings.
Journal ArticleDOI
TGFβ–SMAD signal transduction: molecular specificity and functional flexibility
TL;DR: Current research is focused on the mechanisms that regulate SMAD activity to evoke cell-type-specific and context-dependent transcriptional programmes and the functional role of signal strength and duration.
Journal ArticleDOI
Targeting the TGFβ signalling pathway in disease.
Rosemary J. Akhurst,Akiko Hata +1 more
TL;DR: Why the TGFβ signalling pathway is a drug target, the potential clinical applications of TGF β inhibition, the issues arising with anti-TGFβ therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens are considered.
Related Papers (5)
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Rik Derynck,Ying E. Zhang +1 more