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Journal ArticleDOI

Bibenzyl derivatives from the orchid Bulbophyllum protractum

01 Jan 1997-Phytochemistry (Pergamon)-Vol. 44, Iss: 1, pp 167-172
TL;DR: In this paper, two new bibenzyl derivatives were isolated from the orchid Bulbophyllum protractum and designated bulbophyllin and bulbophilusidin.
About: This article is published in Phytochemistry.The article was published on 1997-01-01. It has received 31 citations till now. The article focuses on the topics: Bibenzyl.
Citations
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Journal ArticleDOI
TL;DR: Two minor metabolites of the whole plant of Bulbophyllum vaginatum collected in Singapore were identified as the biphenanthrene 1 and the phenanthro[4,3-b]furan derivative 2.
Abstract: Two minor metabolites of the whole plant of Bulbophyllum vaginatum collected in Singapore were identified as the biphenanthrene 1 and the phenanthro[4,3-b]furan derivative 2. Structure determinations were performed using a combination of 1D and 2D NMR techniques.

30 citations

Journal ArticleDOI
TL;DR: Four new bibenzyl derivatives, named dendrosinens A–D (1–4), together with twelve known phenolic compounds were isolated from the whole plant of Dendrobium sinense T. T. Wang, an endemic and endangered orchid in Hainan Island, PR China.

27 citations

Journal ArticleDOI
TL;DR: Five new compounds, dencryol A, Dencryol B, crystalltone, crystallinin, and 3-hydroxy-2-methoxy-5,6-dimethylbenzoic acid, together with six known compounds, have been isolated from the stems of Dendrobium crystallinum.

27 citations

Journal ArticleDOI
TL;DR: Cytotoxicity tests of the isolated compounds showed that 6-hydroxy-3-methyl-8-phenylethylbenzo[b]oxepin-5-one (8) showed activity against the human cancer cell lines MCF-7, PC-3, and SMMC-7721, with IC50 values of 3.86, 6.60, and 3.58 μM, respectively.
Abstract: Six new pairs of bibenzyl-based meroterpenoid enantiomers, (±)-rasumatranin A-D (1-4) and (±)-radulanin M and N (5 and 6), and six known compounds were isolated from the adnascent Chinese liverwort, Radula sumatrana. Their structures were elucidated based on spectroscopic data and chiral phase HPLC-ECD analyses. The structures of 1 and 7 were also confirmed by single-crystal X-ray diffraction analysis. Cytotoxicity tests of the isolated compounds showed that 6-hydroxy-3-methyl-8-phenylethylbenzo[b]oxepin-5-one (8) showed activity against the human cancer cell lines MCF-7, PC-3, and SMMC-7721, with IC50 values of 3.86, 6.60, and 3.58 μM, respectively, and induced MCF-7 cell death through a mitochondria-mediated apoptosis pathway.

26 citations

Journal ArticleDOI
TL;DR: The novelty of this review is a summary of biological actions from preclinical studies, thus supporting ethnopharmacological data, that were collected from several scientific databases such as PubMed and ScienceDirect, other professional websites, and traditional medicine books.
Abstract: The genus Bulbophyllum is of scientific interest due to the phytochemical components and diverse biological activities found across species of the genus. Most Bulbophyllum species are epiphytic and located in habitats that range from subtropical dry forests to wet montane cloud forests. In many cultures, the genus Bulbophyllum has a religious, protective, ornamenting, cosmetic, and medicinal role. Detailed investigations into the molecular pharmacological mechanisms and numerous biological effects of Bulbophyllum spp. remain ambiguous. The review focuses on an in-depth discussion of studies containing data on phytochemistry and preclinical pharmacology. Thus, the purpose of this review was to summarize the therapeutic potential of Bulbophyllum spp. biocompounds. Data were collected from several scientific databases such as PubMed and ScienceDirect, other professional websites, and traditional medicine books to obtain the necessary information. Evidence from pharmacological studies has shown that various phytoconstituents in some Bulbophyllum species have different biological health-promoting activities such as antimicrobial, antifungal, antioxidant, anti-inflammatory, anticancer, and neuroprotective. No toxicological effects have been reported to date. Future clinical trials are needed for the clinical confirmation of biological activities proven in preclinical studies. Although orchid species are cultivated for ornamental purposes and have a wide traditional use, the novelty of this review is a summary of biological actions from preclinical studies, thus supporting ethnopharmacological data.

25 citations

References
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Journal ArticleDOI
TL;DR: All the bibenzyls caused leukemia cells to accumulate in mitosis at cytotoxic drug concentrations; however, a wide range of in vitro activity against the protein tubulin (the major component of the mitotic spindle) was observed.
Abstract: Further investigation of a CH2Cl2 fraction prepared from the South African tree Combretum caffrum for substances inhibitory to the murine P-388 lymphocytic leukemia (PS system) cell line has led to the isolation of two new bibenzyls, designated combretastatins B-3 and B-4, accompanied by the previously known bibenzyls 7, 8, and 9. The structure of each substance was ascertained by results of mass and nmr spectral analyses and confirmed by crystal structure determination (for 7) or synthesis. Combretastatins B-3 and B-4 gave PS ED50 values of 0.4 and 1.7 micrograms/ml, respectively, and bibenzyls 7, 8, and 9 were comparably cell growth inhibitory against the PS cell line with ED50 results of 1.7, 2.5, and 0.25 ug/ml, respectively. All the bibenzyls caused leukemia cells to accumulate in mitosis at cytotoxic drug concentrations; however, a wide range of in vitro activity against the protein tubulin (the major component of the mitotic spindle) was observed.

79 citations

Journal ArticleDOI
TL;DR: 2,7-Dihydroxy-4-methoxy-9,10-dihydrophenanthrene was isolated and identified from the whole plant of Coelogyne ochracea and C. elata.

77 citations

Journal ArticleDOI
TL;DR: Three new substituted bibenzyls (1,2-diarylethanes) aloifol I and aloIFol II and a new substituted 9,10-dihydrophenanthrene, 6-O-methylcoelonin in addition to batatasin III, coel onin and gigantol have been isolated and characterized.

70 citations

Journal ArticleDOI
TL;DR: Lusianthrin and lusian-thridin, two new stilbenoids, were isolated from the orchid Lusia indivisa.

66 citations

Journal ArticleDOI
TL;DR: Flavanthrin, the first dimeric 9,10-dihydrophenanthrene derivative, was isolated from the orchid Eria flava which also yielded the previously reported 9, 10-dibhrenanthrene coelonin this paper.

54 citations