Bimodal fibrous structures for tissue engineering: Fabrication, characterization and in vitro biocompatibility

doi:10.1016/J.JCIS.2016.02.048

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Bimodal fibrous structures for tissue engineering: Fabrication, characterization and in vitro biocompatibility

Journal Article•DOI•

Bimodal fibrous structures for tissue engineering: Fabrication, characterization and in vitro biocompatibility

Arjun Prasad Tiwari¹, Mahesh Kumar Joshi¹, Jeong In Kim¹, Afeesh Rajan Unnithan¹, Joshua Lee¹, Chan Hee Park¹, Cheol Sang Kim¹ - Show less +3 more•Institutions (1)

Chonbuk National University¹

15 Aug 2016-Journal of Colloid and Interface Science (Academic Press)-Vol. 476, pp 29-34

TL;DR: Results revealed that the blending of albumin, a hydrophilic biomolecule, with PCL, a Hydrophobic polymer, proves to be an outstanding approach to developing membranes with controlled spider-web-like nano-nets for tissue engineering.

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About: This article is published in Journal of Colloid and Interface Science.The article was published on 2016-08-15. It has received 28 citations till now. The article focuses on the topics: Electrospinning & Membrane.

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Fabrication of Electrospun Polymer Nanofibers with Diverse Morphologies

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Chenyu Wang¹, Jun Wang², Liangdan Zeng², Ziwen Qiao², Xiaochen Liu², He Liu³, Jin Zhang², Jianxun Ding³ - Show less +4 more•Institutions (3)

Hallym University¹, Fuzhou University², Chinese Academy of Sciences³

26 Feb 2019-Molecules

TL;DR: By carefully regulating the operating condition, modifying needle device, optimizing properties of the polymer solutions, some unique structures of core–shell, side-by-side, multilayer, hollow interior, and high porosity can be obtained.

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Abstract: Fiber structures with nanoscale diameters offer many fascinating features, such as excellent mechanical properties and high specific surface areas, making them attractive for many applications. Among a variety of technologies for preparing nanofibers, electrospinning is rapidly evolving into a simple process, which is capable of forming diverse morphologies due to its flexibility, functionality, and simplicity. In such review, more emphasis is put on the construction of polymer nanofiber structures and their potential applications. Other issues of electrospinning device, mechanism, and prospects, are also discussed. Specifically, by carefully regulating the operating condition, modifying needle device, optimizing properties of the polymer solutions, some unique structures of core–shell, side-by-side, multilayer, hollow interior, and high porosity can be obtained. Taken together, these well-organized polymer nanofibers can be of great interest in biomedicine, nutrition, bioengineering, pharmaceutics, and healthcare applications.

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194 citations

Cites background from "Bimodal fibrous structures for tiss..."

...The shape and diameter of the obtained polymer structure are not only affected by the molecular weight, viscosity, electrical conductivity, surface tension [21], but also the voltage applied during electrospinning, the distance from the tip to the collector [22], and the feeding speed [23]....
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...shape and diameter of the obtained polymer structure are not only affected by the molecular weight, viscosity, electrical conductivity, surface tension [21], but also the voltage applied during electrospinning, the distance from the tip to the collector [22], and the feeding speed [23]....
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Journal Article•DOI•

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering.

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Deval Prasad Bhattarai¹, Ludwig Erik Aguilar¹, Chan Hee Park¹, Cheol Sang Kim¹•Institutions (1)

Chonbuk National University¹

14 Aug 2018

TL;DR: This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds, and the current development and future perspectives on the use of Electrospun mats inBone tissue engineering.

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Abstract: Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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171 citations

Journal Article•DOI•

Morphology and Properties of Electrospun PCL and Its Composites for Medical Applications: A Mini Review

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Mokgaotsa Jonas Mochane, T.S. Motsoeneng, Emmanuel Rotimi Sadiku, Teboho Clement Mokhena, Jeremia Shale Sefadi - Show less +1 more

29 May 2019-Applied Sciences

TL;DR: In this paper, a review of different methods for the electrospinning of polycaprolactone (PCL) and its composites for advanced applications is presented, and the steady state conditions as well as the effect of the electro-spinning parameters on the resultant morphology of electrospun fiber are also reported.

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Abstract: Polycaprolactone (PCL) is one of the most used synthetic polymers for medical applications due to its biocompatibility and slow biodegradation character. Combining the inherent properties of the PCL matrix with the characteristic of nanofibrous particles, result into promising materials that can be suitable for different applications, including the biomedical applications. The advantages of nanofibrous structures include large surface area, a small diameter of pores and a high porosity, which make them of great interest in different applications. Electrospinning, as technique, has been heavily used for the preparation of nano- and micro-sized fibers. This review discusses the different methods for the electrospinning of PCL and its composites for advanced applications. Furthermore, the steady state conditions as well as the effect of the electrospinning parameters on the resultant morphology of the electrospun fiber are also reported.

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115 citations

Cites methods from "Bimodal fibrous structures for tiss..."

...In addition, the blending of PCL with other synthetic polymers with different properties for the preparation of polymer blends, after which the fabricated fillers can be introduced to the blends to afford PCL/blends composites with tremendous enhancement of the mechanical properties [79,83,84]....
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Journal Article•DOI•

Novel poly(ε-caprolactone)/amino-functionalized tannin electrospun membranes as scaffolds for tissue engineering

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Alessandro F. Martins¹, Suelen P. Facchi, Paulo C.F. da Câmara¹, Samira Esteves Afonso Camargo¹, Carlos Henrique Camargo¹, Ketul C. Popat¹, Matt J. Kipper¹ - Show less +3 more•Institutions (1)

Colorado State University¹

01 Sep 2018

TL;DR: A new polymer (a hydrophilic amino-functionalized tannin (TN) that is associated with PCL for developing PCL-TN blends at different PCL:TN weight ratios (100:0, 95:5, 85:15 and 78:22) is reported.

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Abstract: Poly(e-caprolactone) (PCL) is a hydrophobic and cytocompatible aliphatic polyester that has been used to produce PCL-based nanofibrous for both wound healing and tissue repair. However, the high hydrophobicity and low water adsorptive have been challenges for developing PCL-based materials for use in tissue engineering field. Here, we report a new polymer (a hydrophilic amino-functionalized tannin (TN)) that is associated with PCL for developing PCL-TN blends at different PCL:TN weight ratios (100:0, 95:5, 85:15 and 78:22). PCL:TN ratio may be tuned to modulate hydrophilicity and cytocompatibility of the nanofibers. The neutralization step and surface wettability played an important role in the attachment of human adipose-derived stem cells (ADSC cells) on PCL-TN membranes. Also, fluorescence images confirmed great proliferation of ADSC cells on the PCL-TN electrospun surfaces. Yet, neutralized PCL-TN nanofibers promoted bactericidal activity against Pseudomonas aeruginosa. These membranes have potential to be used as scaffolds for tissue engineering purposes.

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64 citations

Journal Article•DOI•

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

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Samerender Nagam Hanumantharao, Smitha Rao

19 Jul 2019-Fibers

TL;DR: A review of polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning is presented in this paper, where a brief theory of electro-spinning and the general setup as well as modifications used are presented.

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Abstract: Electrospinning and polymer blending have been the focus of research and the industry for their versatility, scalability, and potential applications across many different fields. In tissue engineering, nanofiber scaffolds composed of natural fibers, synthetic fibers, or a mixture of both have been reported. This review reports recent advances in polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning. A brief theory of electrospinning and the general setup as well as modifications used are presented. Polymer blends, including blends with natural polymers, synthetic polymers, mixture of natural and synthetic polymers, and nanofiller systems, are discussed in detail and reviewed.

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59 citations

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Journal Article•DOI•

Biomimetic electrospun nanofibrous structures for tissue engineering

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Xianfeng Wang¹, Bin Ding¹, Bingyun Li²•Institutions (2)

Donghua University¹, West Virginia University²

01 Jun 2013-Materials Today

TL;DR: This review provides a brief overview of current state-of-the-art research designing and using biomimetic electrospun nanofibers as scaffolds for tissue engineering.

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640 citations

"Bimodal fibrous structures for tiss..." refers background in this paper

...extremely large surface area/volume ratio and enhanced mechanical properties [8, 10-12]....
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Journal Article•DOI•

Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets

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Xianfeng Wang¹, Bin Ding¹, Gang Sun¹, Moran Wang², Jianyong Yu¹ - Show less +1 more•Institutions (2)

Donghua University¹, Tsinghua University²

01 Oct 2013-Progress in Materials Science

TL;DR: The used polymers and the state-of-the-art strategies for the controllable fabrication of NFN membranes are highlighted in terms of the ESN process and some potential applications associated with the remarkable features ofNFN nanostructure are highlighted.

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435 citations

"Bimodal fibrous structures for tiss..." refers background in this paper

...Several studies have reported that the addition of salts increases the conductivity of the polymer solution, which is essential to the formation of the nano-nets in an electrospun membrane [16, 17]....
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...Further increasing the voltage (15 and 20 kV), nano-nets were found ruptured and distorted which might be due to higher electrostatic forces [16]....
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Journal Article•DOI•

Electrospinning of polymer nanofibers for tissue regeneration

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Tao Jiang¹, Erica J. Carbone¹, Kevin W.-H. Lo, Cato T. Laurencin•Institutions (1)

University of Connecticut Health Center¹

01 Jul 2015-Progress in Polymer Science

TL;DR: Current strategies to develop advanced nan ofibrous polymer-based scaffolds via electrospinning, their applications in regenerating human musculoskeletal tissues, and the use of polymer nanofibers to deliver growth factors or small molecules for regenerative medicine are summarized.

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381 citations

"Bimodal fibrous structures for tiss..." refers methods in this paper

...widely used technique to produce nanofibrous mesh for biomedical applications due to its versatility and cost effectiveness [6]....
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Journal Article•DOI•

Extracellular matrix regenerated : tissue engineering via electrospun biomimetic nanofibers

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Scott A. Sell¹, Catherine P. Barnes¹, Matthew J. Smith¹, Michael J. McClure¹, Parthasarathy Madurantakam¹, Joshua Grant¹, Michael C. McManus¹, Gary L. Bowlin¹ - Show less +4 more•Institutions (1)

Virginia Commonwealth University¹

01 Nov 2007-Polymer International

TL;DR: The role of electrospinning is highlighted in the engineering of different tissues and applications (skin/wound healing, cartilage, bone, vascular tissue, urological tissues, nerve, and ligament), and its potential role in future work is discussed.

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Abstract: While electrospinning had seen intermittent use in the textile industry from the early twentieth century, it took the explosion of the field of tissue engineering, and its pursuit of biomimetic extracellular matrix (ECM) structures, to create an electrospinning renaissance. Over the past decade, a growing number of researchers in the tissue engineering community have embraced electrospinning as a polymer processing technique that effectively and routinely produces non-woven structures of nanoscale fibers (sizes of 80 nm to 1.5 µm). These nanofibers are of physiological significance as they closely resemble the structure and size scale of the native ECM (fiber diameters of 50 to 500 nm). Attempts to replicate the many roles of native ECM have led to the electrospinning of a wide array of polymers, both synthetic (poly(glycolic acid), poly(lactic acid), polydioxanone, polycaprolactone, etc.) and natural (collagen, fibrinogen, elastin, etc.) in origin, for a multitude of different tissue applications. With various compositions, fiber dimensions and fiber orientations, the biological, chemical and mechanical properties of the electrospun materials can be tailored. In this review we highlight the role of electrospinning in the engineering of different tissues and applications (skin/wound healing, cartilage, bone, vascular tissue, urological tissues, nerve, and ligament), and discuss its potential role in future work. Copyright © 2007 Society of Chemical Industry

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210 citations

"Bimodal fibrous structures for tiss..." refers background in this paper

...Membranes developed via electrospinning are composed of mostly sub-micron fibers (100nm to 1μm diameter) and resemble extracellular matrices [7]....
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Journal Article•DOI•

Formation of novel 2D polymer nanowebs via electrospinning

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Bin Ding¹, Chunrong Li, Yasuhiro Miyauchi¹, Oriha Kuwaki¹, Seimei Shiratori¹ - Show less +1 more•Institutions (1)

Keio University¹

14 Aug 2006-Nanotechnology

TL;DR: In this paper, a procedure for generating novel two-dimensional (2D) nanowebs in 3D fibrous mats by optimization of various processing parameters during electrospinning is presented.

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Abstract: We have found a procedure for generating novel two-dimensional (2D) nanowebs in three-dimensional (3D) fibrous mats by optimization of various processing parameters during electrospinning. The electrospun fibres act as a support for the 'fishnet-like' nanowebs comprising interlinked one-dimensional (1D) nanowires. The average diameter of the nanowires contained in typical nanowebs is about one order of magnitude less than that of conventional electrospun fibres. The formation of the nanowebs of poly(acrylic acid) (PAA) and nylon-6 is considered to be due to the electrically forced fast phase separation of the charged droplets which move at high speed between the capillary tip and the collector. The formation, morphology and area density of the nanowebs in electrospun fibrous mats are strongly affected by the applied voltage, ambient relative humidity, kinds of solvents, solution concentration and distance between the capillary tip and the collector.

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208 citations

"Bimodal fibrous structures for tiss..." refers background in this paper

...6 PCL-HSA mat might be attributed to the rapid phase separation of polymer-rich and polymerpoor regions during electrospinning [13]....
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...The structure and morphology of the electrospun membranes are affected by the composition of the electrospinning solution and its physical properties such as conductivity, viscosity and surface tension [11, 13]....
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...polymer-rich region while the polymer-poor region contributes to the formation of the nano-nets [13, 14, 18]....
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...Later, Polymer-poor region might have contributed to the formation of the nano-nets due to the electrostatic force, columbic repulsive forces, and drag forces that act upon the charged molecules [13, 18]....
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...first time reported the formation of nano-webs of poly (acrylic acid) and nylon-6 and inferred that nano-nets can be obtained by controlling the various electrospinning parameters such as solution conductivity and viscosity, solution feeding rate, applied voltage and distance [13]....
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