Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.
Yuan C. Lee,R.Reid Townsend,Mark R. Hardy,Jörgen Lönngren,Jan Arnarp,Martin Haraldsson,H Lönn +6 more
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TLDR
It was found that the number of Gal residues/cluster and their branching mode are major determinants of binding affinity of ligands to the hepatic lectin on the surface of hepatocytes.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-01-10 and is currently open access. It has received 475 citations till now. The article focuses on the topics: Ligand (biochemistry) & Lectin.read more
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Carbohydrate-Protein Interactions: Basis of Glycobiology
Yuan C. Lee,R. T. Lee +1 more
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Multivalent engagement of chromatin modifications by linked binding modules.
TL;DR: It is proposed that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions.
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Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.
Toshiharu Eto,Hiroshi Takahashi +1 more
TL;DR: It is demonstrated that directing IFN to ASGP receptor facilitates its signaling in the liver and augments its antiviral effect, and is therefore useful in overcoming the limited antiviral effects of conventional IFNs.
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Functional dendrimers, hyperbranched and star polymers
TL;DR: In this article, the synthesis, properties, and functionality of dendrimers, hyperbranched polymers, and star polymers with emphasis on functional aspects are reviewed.
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Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair,Jennifer L. S. Willoughby,Amy Chan,Klaus Charisse,Md. Rowshon Alam,Qianfan Wang,Menno Hoekstra,Pachamuthu Kandasamy,Alexander V Kel'in,Stuart Milstein,Nate Taneja,Jonathan O'Shea,Sarfraz Shaikh,Ligang Zhang,Ronald J. van der Sluis,Michael E. Jung,Akin Akinc,Renta Hutabarat,Satya Kuchimanchi,Kevin Fitzgerald,Tracy Zimmermann,Theo J.C. Van Berkel,Martin Maier,Kallanthottathil G. Rajeev,Muthiah Manoharan +24 more
TL;DR: The optimally chemically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to treat a wide range of diseases involving liver-expressed genes.
References
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The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
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Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency
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Determination of the primary structures of 16 asialo-carbohydrate units derived from human plasma alpha 1-acid glycoprotein by 360-MHZ 1H NMR spectroscopy and permethylation analysis.
Bernard Fournet,Jean Montreuil,Gérard Strecker,Lambertus Dorland,Johan Haverkamp,Vliegenthart Fg,J.P. Binette,Karl Schmid +7 more
TL;DR: In this paper, the primary structures of the carbohydrate units of human plasma al-acid glycoprotein were determined in a very short period of time using NMR spectroscopy.
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2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteins.
TL;DR: The IME-thioglycosides constitute a new group of reagents for attaching sugars to proteins in mildly alkaline buffer solutions and Alpha-amylase and lysozyme modified with these reagents under appropriate conditions retained full activities.
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Structural studies on the carbohydrate portion of fetuin.
TL;DR: The O-glycosidically linked carbohydrate chains of fetuin have been cleaved off by alkaline borohydride treatment and separated from the iV-glyCosidically link carbohydrate chains still bound to the protein, and the following structures are proposed.