Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies

doi:10.1080/07391102.2020.1759454

Home
/
Papers
/
Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies

Journal Article•DOI•

Bio-active mixed ligand Cu(II) and Zn(II) complexes of pyrimidine derivative Schiff base: DFT calculation, antimicrobial, antioxidant, DNA binding, anticancer and molecular docking studies

Nagaraj Revathi¹, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja², Gujuluva Gangatharan Vinoth Kumar¹, A. Sakthivel³, R. Rajasekaran⁴ - Show less +2 more•Institutions (4)

Sethu Institute of Technology¹, American College, Madurai², Mepco Schlenk Engineering College³, VIT University⁴

05 May 2020-Journal of Biomolecular Structure & Dynamics (Taylor & Francis)-Vol. 39, Iss: 8, pp 1-13

TL;DR: In vitro cytotoxicity of the Schiff base (HL) and complexes 1–4 shows that complex 1 shows better ability to inhibit the growth of cancer cells and may be an appreciated material in cancer chemotherapy mediators in imminent years.

read less

Abstract: A new series of bio active Cu(II) and Zn(II) complexes [CuL(phen)](OOCCH3) (1), [ZnL(phen)](OOCCH3) (2), [CuL(bpy)](OOCCH3) (3), [ZnL(bpy)](OOCCH3) (4) have been synthesized using the pyrimidine de...

...read moreread less

Citations

PDF

Open Access

More filters

Journal Article•DOI•

Synthesis, characterization, powder X-ray diffraction analysis, thermal stability, antioxidant properties and enzyme inhibitions of M(II)-Schiff base ligand complexes.

[...]

Kenan Buldurun¹, Nevin Turan¹, Ercan Bursal¹, Abdülmelik Aras², Asim Mantarcı¹, Naki Çolak³, Fikret Türkan², İlhami Gülçin⁴ - Show less +4 more•Institutions (4)

Muş Alparslan University¹, Iğdır University², Hittite University³, Atatürk University⁴

22 Nov 2021-Journal of Biomolecular Structure & Dynamics

TL;DR: The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II] and palladium(II) complexes were successfully prepared and the structure was elucidated by various techniques.

...read moreread less

Abstract: The Schiff base ligand ((E)-6-methyl-2-(2,3,4-trimethoxybenzylideneamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile) and its cobalt(II) and palladium(II) complexes were successfully prepar...

...read moreread less

24 citations

Cites background from "Bio-active mixed ligand Cu(II) and ..."

...Moreover, ruthenium and palladium complexes, have been used as catalysts in numerous heterogeneous and homogeneous reactions (Elsayed et al., 2017; Gaber et al., 2015; Revathi et al., 2020; Zianna et al., 2019)....
[...]

Journal Article•DOI•

Synthesis, characterization and DNA interaction of a novel Pt(II) macroacyclic Schiff base complex containing the piperazine moiety and its cytotoxicity and molecular docking

[...]

Leila Nemati¹, Hassan Keypour¹, Nahid Shahabadi², Saba Hadidi², Robert W. Gable³ - Show less +1 more•Institutions (3)

Bu-Ali Sina University¹, Razi University², University of Melbourne³

01 Sep 2021-Journal of Molecular Liquids

TL;DR: In this paper, a new platinum Schiff base complex, [C17H28N4OPt]Cl2 (1) was prepared from the condensation of a polyamine containing piperazine moiety, (1,4-bis(3-aminopropyl)piperazine) and 2-hydroxy-benzaldehyde (H2L), in the presence of Pt2+ ion and examined by mass, FT-IR, elemental analysis 1H NMR and 13C NMR.

...read moreread less

18 citations

Journal Article•DOI•

Biologically relevant and energetically significant cooperative ternary (π–π)2/(π–π)1/(π–π)2 assemblies and fascinating discrete (H2O)21 clusters in isostructural 2,5-pyridine dicarboxylato Co(II) and Zn(II) phenanthroline compounds: antiproliferative evaluation and theoretical studies

[...]

Sanjib Chetry, Pranay Sharma, Antonio Frontera, Utpal Saha, Akalesh K. Verma, Bipul Sarma¹, Paran Jyoti Kalita², Manjit K. Bhattacharyya - Show less +4 more•Institutions (2)

Tezpur University¹, North East Institute of Science and Technology²

22 Feb 2021-New Journal of Chemistry

TL;DR: In this article, two new isostructural coordination compounds of cobalt and zinc involving 1,10-phenanthroline and 2,5-pyridine dicarboxylate were synthesized and characterised using FT-IR, electronic spectroscopy, thermal analysis, elemental analysis and single crystal X-ray diffraction techniques.

...read moreread less

Abstract: Two new isostructural coordination compounds of cobalt(II) and zinc(II) involving 1,10-phenanthroline and 2,5-pyridine dicarboxylate, viz., [Co(2,5-PDC)(phen)2]·9H2O (1) and [Zn(2,5-PDC)(phen)2]·9H2O (2) (in which, PDC = pyridine dicarboxylate, phen = 1,10-phenanthroline) have been synthesized and characterised using FT-IR, electronic spectroscopy, thermal analysis, elemental analysis and single crystal X-ray diffraction techniques. Crystal structure analysis reveals that the neighboring monomeric units of 1 and 2 are self-assembled via π-stacking, C–H⋯π and C–H⋯O interactions. Fascinating and unusual discrete (H2O)21 clusters in 2 stabilize the network architecture. The self-assembled enclathration of water clusters in the hexameric supramolecular host cavity of 1 provides additional reinforcement to the crystal structure. The strength of the biologically relevant cooperative π-stacking interactions for 1 and 2 has been investigated using DFT calculations and analyzed using an NCI plot index. Remarkably, the (π–π)1 binding modes in the ternary π-stacked assemblies are energetically more significant than the (π–π)2 mode due to the contribution of the two symmetrically related C–H⋯O interactions. The large and almost identical dipole moments of the compounds nullify the influence of the metal centers on the strength of the cooperative π-stacked assemblies, and this corroborates the strong binding energies. The compounds significantly induce concentration dependent cell cytotoxicity and apoptosis in DL cancer cells with negligible cytotoxicity in normal cells. The molecular docking study and pharmacophore features establish the structure activity relationship (SAR) of the compounds.

...read moreread less

17 citations

Journal Article•DOI•

Synthesis and toxicity assessment of Fe3O4 NPs grafted by ∼ NH2-Schiff base as anticancer drug: modeling and proposed molecular mechanism through docking and molecular dynamic simulation.

[...]

Rahime Eshaghi Malekshah¹, Bahareh Fahimirad¹, Mohammadreza Aallaei², Ali Khaleghian¹•Institutions (2)

Semnan University¹, Imam Hossein University²

10 Aug 2020-Drug Delivery

TL;DR: It is found that the higher toxicity of Fe3O4@SiO2@APTS ∼ Schiff base-Cu(II) (IC50: 1000 μg/mL) is due to their stronger in situ degradation, with larger intracellular release of iron ions, as compared to surface passivated NPs.

...read moreread less

Abstract: Superparamagnetic iron oxide nanoparticles have been synthesized using chain length of (3-aminopropyl) triethoxysilane for cancer therapy. First, we have developed a layer by layer functionalized w...

...read moreread less

16 citations

Cites background from "Bio-active mixed ligand Cu(II) and ..."

...C¼N–) (Irfan et al., 2020; Revathi et al., 2020)....
[...]
...They can be synthesized with different metal ions that show desirable activities via azomethine nitrogen atom (–C1⁄4N–) (Irfan et al., 2020; Revathi et al., 2020)....
[...]

Journal Article•DOI•

DNA/BSA binding affinity studies of new Pd(II) complex with S-S and N-N donor mixed ligands via experimental insight and molecular simulation: Preliminary antitumor activity, lipophilicity and DFT perspective

[...]

Mehran Feizi-Dehnayebi¹, Effat Dehghanian¹, Hassan Mansouri-Torshizi¹•Institutions (1)

University of Sistan and Baluchestan¹

21 Oct 2021-Journal of Molecular Liquids

TL;DR: In this paper, a novel water-like palladium(II) complex, [Pd(phen)(proli-dtc)]NO3 (phen = 1,10-phenanthroline and proli -dtc = pyrrolinedithiocarbamate), has been prepared.

...read moreread less

16 citations

1
2
3
4
…
5

References

PDF

Open Access

More filters

Journal Article•DOI•

Antioxidant Determinations by the Use of a Stable Free Radical

[...]

Marsden S. Blois¹•Institutions (1)

Stanford University¹

01 Apr 1958-Nature

TL;DR: In this paper, the chemical nature of the antioxidant is known and a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups.

...read moreread less

Abstract: METHODS for measuring antioxidants and appraising antioxidant activity appear to be of two general types. If the chemical nature of the antioxidant is known, one may strive for a test specific for the compound or group of interest; for example, the nitroprusside test for sulphydryl groups. Alternatively one may observe the inhibition of some natural oxidative process such as the β-oxidation of fats, as a function of the added antioxidant.

...read moreread less

10,611 citations

"Bio-active mixed ligand Cu(II) and ..." refers methods in this paper

...The DPPH radical scavenging activity of the Schiff base (HL) and complexes 1–4 is measured using Blois method (Blois, 1958)....
[...]

Journal Article•

The use of the stable free radical diphenylpicrylhydrazyl (dpph) for estimating antioxidant activity

[...]

Philip Molyneux

01 Jan 2004-Songklanakarin Journal of Science and Technology (SJST)

TL;DR: The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity and its application in antioxidant research is described.

...read moreread less

Abstract: Molyneux, P. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity

...read moreread less

2,519 citations

"Bio-active mixed ligand Cu(II) and ..." refers background in this paper

...Antioxidants are our first line to defence against free radical damage, the need for antioxidants become even more critical with increased exposure to free radicals pollution, cigarette smoke, drugs, illness, stress and even exercise can increase free radical exposure (Adwin Jose et al., 2020; Molyneux, 2004)....
[...]
...…are our first line to defence against free radical damage, the need for antioxidants become even more critical with increased exposure to free radicals pollution, cigarette smoke, drugs, illness, stress and even exercise can increase free radical exposure (Adwin Jose et al., 2020; Molyneux, 2004)....
[...]

Journal Article•DOI•

The electronic properties and stereochemistry of mono-nuclear complexes of the copper(II) ion

[...]

B.J. Hathaway¹, D.E. Billing¹•Institutions (1)

University of Essex¹

01 Jul 1970-Coordination Chemistry Reviews

2,329 citations