Bioactive coumarins from Boenninghausenia sessilicarpa
28 Feb 2007-Journal of Asian Natural Products Research (J Asian Nat Prod Res)-Vol. 9, Iss: 1, pp 59-65
TL;DR: Bioassay guided fractionation of Boenninghausenia sessilicarpa resulted in the isolation of a new dimeric coumarin glucoside 9′-methoxyl rutarensin and a cytotoxic compound rutamarin, as well as an antivirus component leptodactylone, together with six known coumarins.
About: This article is published in Journal of Asian Natural Products Research.The article was published on 2007-02-28. It has received 41 citations till now. The article focuses on the topics: Boenninghausenia.
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TL;DR: It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
273 citations
TL;DR: A comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS are provided, and their potential use for the treatment of COVID-19 is discussed.
121 citations
TL;DR: In this article, a review of plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.
Abstract: New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19) declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2). SARS-CoV-2 is akin to SARS-CoV, which was the causative agent of severe acute respiratory syndrome (SARS) in 2002 as well as to that of Middle East respiratory syndrome (MERS) in 2012. SARS-CoV-2 has been revealed to belong to Coronaviridiae family as a member of β-coronaviruses. It has a positive-sense single-stranded RNA with the largest RNA genome. Since its genomic sequence has a notable similarity to that of SARS-CoV, antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 treatment. In order to combat SARS-CoV-2, many drug and vaccine development studies at experimental and clinical levels are currently conducted worldwide. In this sense, medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of coronaviruses. In the present review, plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.
84 citations
26 Jun 2020
TL;DR: Several of the potent antiviral chemical constituents extracted from medicinal and aromatic plants, natural products, and herbal medicines with recognized in vitro and in vivo effects are illustrated, along with their structure–effect relationships.
Abstract: After its recent discovery in patients with serious pneumonia in Wuhan (China), the 2019 novel coronavirus (2019-nCoV), named also Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has spread quickly Unfortunately, no drug or vaccine for treating human this coronavirus infection is available yet Numerous options for controlling or preventing emerging 2019-nCoV infections may be predicted, including vaccines, interferon therapies, and small-molecule drugs However, new interventions are likely to require months to years to develop In addition, most of the existing antiviral treatments frequently lead to the development of viral resistance combined with the problem of side effects, viral re-emergence, and viral dormancy The pharmaceutical industry is progressively targeting phytochemical extracts, medicinal plants, and aromatic herbs with the aim of identifying lead compounds, focusing principally on appropriate alternative antiviral drugs Spices, herbal medicines, essential oils (EOs), and distilled natural products provide a rich source of compounds for the discovery and production of novel antiviral drugs The determination of the antiviral mechanisms of these natural products has revealed how they interfere with the viral life cycle, ie, during viral entry, replication, assembly, or discharge, as well as virus-specific host targets Presently, there are no appropriate or approved drugs against CoVs, but some potential natural treatments and cures have been proposed Given the perseverance of the 2019-nCoV outbreak, this review paper will illustrate several of the potent antiviral chemical constituents extracted from medicinal and aromatic plants, natural products, and herbal medicines with recognized in vitro and in vivo effects, along with their structure–effect relationships As this review shows, numerous potentially valuable aromatic herbs and phytochemicals are awaiting assessment and exploitation for therapeutic use against genetically and functionally different virus families, including coronaviruses
83 citations
01 Aug 2013
TL;DR: HPLC chromatograms revealed the production of glycoside digoxin from the five selected endophytic cultures, thus providing a novel, alternative and eco-friendly source for theproduction of such a pharmaceutically important and valuable drug.
Abstract: Endophytes, the chemical synthesizers inside plants, are the microorganisms having mutualistic relationship with the host plant. They can be used by plants for defense in addition to the production of a wide variety of beneficial bioactive secondary metabolites. There are reports that microbial endophytes mimic the bioactive compounds as produced by the plant itself thus making them a promising source of novel compounds. During the present study, endophytes were isolated from the symptomless leaves and stem of the angiosperm, Digitalis lanata (foxglove). Digitalis lanata belongs to the family Plantaginaceae and is an important medicinal plant known for the production of an important glycoside, digoxin having valuable medicinal importance. Glycosides from Digitalis have been reported to be cardiotonic and are widely used in the treatment of various heart conditions namely atrial fibrillation, atrial flutter, heart failure, etc. Endophytic fungi were isolated from Digitalis to screen them for such glycosides as have been found in the plant itself. A total of 35 fungal endophytes were isolated and screened for the production of secondary metabolites. After preliminary analysis by thin layer chromatography for the presence of bioactive compounds, crude extracts of five fungal cultures were selected for HPLC. HPLC chromatograms revealed the production of glycoside digoxin from the five selected endophytic cultures, thus providing a novel, alternative and eco-friendly source for the production of such a pharmaceutically important and valuable drug.
48 citations
References
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TL;DR: In this article, a tricoumarin glycoside, triumbellin and the corresponding aglycone triumbelletin were isolated and structurally elucidated by one and TD-HF-NMR spectroscopy including two dimensional phase sensitive NOE experiments.
35 citations
TL;DR: A new phenol in Leptodactylon and Linanthus leaf has been identified by spectral procedures as 5,7-dimethoxy-8-hydroxycoumarin and its structure has been confirmed by synthesis.
21 citations
20 citations
TL;DR: Toddalenone, a new coumarin, was isolated from Toddalia asiatica (L.) Lam. (T. aculeata Pers.). Its structure was established as the formula (1) by correlation with limettin (2) as discussed by the authors.
Abstract: Toddalenone, a new coumarin, was isolated from Toddalia asiatica (L.) Lam. (T. aculeata Pers.). Its structure was established as the formula (1) by correlation with limettin (2). Vilsmeier-Haack formylation of limettin (2) gave 8-formyllimettin (10) in good yield. Aldol condensation of this material (10) with acetone afforded toddalenone (1).
19 citations
TL;DR: The investigation of a plant cell culture of RUTA CHALEPENSIS L. yielded three compounds: isorutarin, rutacridone, and rutarensin, a so far unknown ester of daphnoretin glucoside ("daphnorin"), as well as 3-hydroxy-3-methylglutaric acid.
Abstract: The investigation of a plant cell culture of RUTA CHALEPENSIS L. yielded three compounds: isorutarin, rutacridone, and rutarensin, a so far unknown ester of daphnoretin glucoside ("daphnorin"), as well as 3-hydroxy-3-methylglutaric acid.
19 citations