Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
About: This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.
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TL;DR: The state-of-the-art on hybrid porous solids, their advantages, their new routes of synthesis, the structural concepts useful for their 'design', aiming at reaching very large pores are presented.
Abstract: This critical review will be of interest to the experts in porous solids (including catalysis), but also solid state chemists and physicists. It presents the state-of-the-art on hybrid porous solids, their advantages, their new routes of synthesis, the structural concepts useful for their ‘design’, aiming at reaching very large pores. Their dynamic properties and the possibility of predicting their structure are described. The large tunability of the pore size leads to unprecedented properties and applications. They concern adsorption of species, storage and delivery and the physical properties of the dense phases. (323 references)
5,187 citations
TL;DR: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers, applicable to virtually every soluble or fusible polymer.
Abstract: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers. This technique is applicable to virtually every soluble or fusible polymer. The polymers can be chemically modified and can also be tailored with additives ranging from simple carbon-black particles to complex species such as enzymes, viruses, and bacteria. Electrospinning appears to be straightforward, but is a rather intricate process that depends on a multitude of molecular, process, and technical parameters. The method provides access to entirely new materials, which may have complex chemical structures. Electrospinning is not only a focus of intense academic investigation; the technique is already being applied in many technological areas.
3,833 citations
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
3,116 citations
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
2,753 citations
Cites background from "Biodegradable polymeric nanoparticl..."
...Depending on the polymer and the surface modification, the zeta potential values may be positive, neutral or negative [16]....
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...The solvent is then evaporated or extracted and the nanoparticles collected after centrifugation [1,16]....
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TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
2,314 citations
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TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Abstract: Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions.
2,827 citations
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Abstract: s, and 360 patents, and edited 12 books. He has also received over 80 major awards including the Gairdner Foundation International Award, Lemelson-MIT prize, ACS’s Applied Polymer Science and Polymer Chemistry Awards, AICHE’s Professional Progress, Bioengineering, Walker and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and the National Academy of Sciences. He is the only active member of all three National Academies. Kevin Shakesheff was born in Ashington, Northumberland, U.K., in 1969. He received his Bacheclor of Pharmacy degree from the University of Nottingham in 1991 and a Ph.D. from the same institution in 1995. In 1996 he became a NATO Postdoctoral Fellow at MIT, Department of Chemical Engineering. He is currently an EPSRC Advanced Fellow at the School of Pharmaceutical Sciences, The University of Nottingham. His research group investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering. 3182 Chemical Reviews, 1999, Vol. 99, No. 11 Uhrich et al.
2,532 citations
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Abstract: Hydrophilic nanoparticulate carriers have important potential applications for the administration of therapeutic molecules. The recently developed hydrophobic-hydrophilic carriers require the use of organic solvents for their preparation and have a limited protein-loading capacity. To address these limitations a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented. The preparation technique, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature. One phase contains the polysaccharide chitosan (CS) and a diblock copolymer of ethylene oxide and propylene oxide (PEO-PPO) and, the other, contains the polyanion sodium tripolyphosphate (TPP). Size (200–1000 nm) and zeta potential (between +20 mV and +60 mV) of nanoparticles can be conveniently modulated by varying the ratio CS/PEO-PPO. Furthermore, using bovine serum albumin (BSA) as a model protein it was shown that these new nanoparticles have a great protein loading capacity (entrapment efficiency up to 80% of the protein) and provide a continuous release of the entrapped protein for up to 1 week. © 1997 John Wiley & Sons, Inc.
1,619 citations
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
1,507 citations
Book•
01 Feb 2014
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
Abstract: Contributors. Foreword by C.A. Vacanti. Preface to the Second Edition. Preface to the First Edition. Tissue Engineering in Perspective, E. Bell. Introduction to Tissue Engineering: The History and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti. The Challenge of Imitating Nature, R.M. Nerem. Part I: The Basis of Growth and Differentiation: Organization of Cells into Higher Ordered Structures, C.A. Erickson. Dynamics of Cell-ECM Interactions, M.Martins-Green. Matrix Molecules and Their Ligands, B.R. Olsen. Inductive Phenomena, M. Hebrok and D. A. Melton. Morphogenesis and Tissue Engineering, A.H. Reddi. Cell Determination and Differentiation, L.W. Browder. Part II: In Vitro Control of Tissue Development: Mechanical and Chemical Determinants of Tissue Development, D.E. Inger. Animal Cell Culture, G.H. Sato and D.W. Barnes. Regulation of Cell Behavior by Matricellular Proteins, A.D. Bradshaw and E.H. Sage. Growth Factors, T.F. Deuel and N. Zhang. Tissue Engineering Bioreactors, L.E. Freed and G. Vunjak-Novakovic. Tissue Assembly in Microgravity, B.R. Unsworth and P.I. Lelkes. Part III: In Vivo Synthesis of Tissues and Organs: In Vivo Synthesis of Tissues and Organs, L.V. Yannas. Part IV: Models for Tissue Engineering: Organotypic and Histiotypic Models of Engineered Tissues, E. Bell. Quantitative Aspects of Tissue Engineering: Basic Issues in Kinetics, Transport, and Mechanics, A.J. Grodzinsky, R.D. Kamm, and Douglas A. Lauffenburger. Part V: Biomaterials in Tissue Engineering: Patterning of Cells and Their Environment, S. Takayama, R.C. Chapman, R.S. Kane, and G.M. Whitesides. Cell Interactions with Polymers, W.M. Saltzman. Matrix Effects, J.A. Hubbell. Polymer Scaffold Processing, R.C. Thomson, A.K. Shung, M.J. Yaszemski, and A.G. Mikos. Biodegradable Polymers, J.M. Pachence and J. Kohn. Part VI: Transplantation of Engineered Cells and Tissues: Approaches to Transplanting Engineered Cells and Tissues, J. Hardin-Young, J. Teumer, R.N. Ross, and N.L. Parenteau. Cryopreservation, J.O.M. Karlsson and M. Toner. Immunomodulation, D. Faustman. Immunoisolation, B.A. Zielinski and M.J. Lysaght. Engineering Challenges in Immunoisolation Device Development, E.S. Avgoustiniatos, H. Wu, and C.K. Colton. Part VII: Fetal Tissue Engineering: Fetal Tissue Engineering, D.O. Fauza. Pluripotent Stem Cells, M.J. Shamblott, B.E. Edwards, and J.D. Gearhart. Part VIII: Gene Therapy: Gene-Based Therapeutics, L.G. Fradkin, J.D. Ropp, and J.F. Warner. Part IX: Breast: Breast Reconstruction, K.Y. Lee, C.R. Halberstadt, W.D. Holder, and D.J. Mooney. Part X: Cardiovascular System: Blood Vessels, L. Xue and H.P. Greisler. Small-Diameter Vascular Grafts, S.J. Sullivan and K.G.M. Brockbank. Cardiac Prostheses, J.W. Love. Part XI: Cornea: Cornea, V. Trinkaus-Randall. Part XII: Endocrinology and Metabolism: Bioartificial Pancreas, T.G. Wang and R.P. Lanza. Parathyroid, C. Hasse, A Zielke, T. Bohrer, U. Zimmerman, and M. Rothmund. Part XIII: Gastrointestinal System: Alimentary Tract, G.M. Organ and J.P. Vacanti. Liver, H.O. Jauregui. Hepat Assist Liver Support System, C. Mullon and B.A. Solomon. Lineage Biology and Liver, A.S.L. Xu, T.L. Luntz, J.M. Macdonald, H. Kubota, E. Hsu, R.E. London, and L.M. Reid. Part XIV: Hematopoietic System: Red Blood Cell Substitutes, T.M.S. Chang. Lymphoid Cells, U. Chen. Hematopoietic Stem Cells, A. Kessinger and G. Sharp. Part XV: Kidney and Genitourinary System: Renal Replacement Devices, H.D. Humes. Genitourinary System, B.-S. Kim, D.J. Mooney, and A. Atala. Part XVI: Musculoskeletal System: Structural Tissue Engineering, C.A. Vacanti, L.J. Bonassar, and J.P. Vacanti. Bone Regeneration through Cellular Engineering, S.P. Bruder and A.I. Caplan. Articular Cartilage Injury, J.M. McPherson and R. Tubo. Tendons and Ligaments, F. Goulet, D. Rancourt, R. Cloutier, L. Germain, A.R. Poole, and F.A. Auger. Mechanosensory Mechanisms in Bone, S.C. Cowin and M.L. Moss. Myoblast Therapy, J.C. Cousins, J.E. Morgan, and T.A. Partridge. Part XVII: Nervous System: Protection and Repair of Hearing, R.A. Altschuler, Y. Raphael, J. Schacht, D.J. Anderson, and J.M. Miller. Vision Enhancement Systems, G. Dagnelie, M.S. Humayun, and R.W. Massof. Brain Implants, Lars U. Wahlberg. Nerve Regeneration, E.G. Fine, R.F. Valentini, and P. Aebischer. Transplantation Strategies for Treatment of Spinal Cord Dysfunction and Injury, J. Sagen, M.B. Bunge, and N. Kleitman. Neural Stem Cells, M.P. Vacanti. Part XVIII: Periodontal and Dental Applications: Periodontal Applications, N.A. Miller, M.C. Bene, J.P., P. Ambrosini, and G.C. Faure. Regeneration of Dentin, R.B. Rutherford. Part XIX: Skin: Wound Repair: Basic Biology to Tissue Engineering, R.A.F. Clark and A.J. Singer. Skin, N.L. Parenteau, J. Hardin-Young, and R.N. Ross. Dermal Equivalents, G.K. Naughton. Part XX: Womb: Artificial Womb, C.S. Muratore and J.M. Wilson. Part XXI: Regulatory Issues: Regulatory Considerations, K.B. Hellman, R.R. Solomon, C. Gaffey, C.N. Durfor, and J.G. Bishop. Epilogue. Index.
1,462 citations