Open Access
Biofilms in dermatology.
Aron G. Nusbaum,Robert S. Kirsner,Carlos A. Charles +2 more
- Vol. 17, Iss: 7, pp 1-5
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TLDR
Though limited treatment options are presently available, better understanding of the molecular biology of biofilms and their pathogenicity will likely lead to the development of novel anti-biofilm agents for clinical use.Abstract:
Biofilms are diverse communities of microorganisms embedded within a self-produced matrix of extracellular polymeric substance which are firmly attached to biotic or abiotic surfaces. Approximately 80% of all human infections are associated with biofilms and evidence for their role in an ever-growing number of cutaneous disorders is constantly unfolding. Biofilms present a difficult challenge to clinicians due to their persistent nature, inability to be cultured with standard techniques, and resistance to conventional antimicrobial therapy. Although limited treatment options are presently available, better understanding of the molecular biology of biofilms and their pathogenicity will likely lead to the development of novel anti-biofilm agents for clinical use.read more
Citations
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Gold Nanoparticle-Photosensitizer Conjugate Based Photodynamic Inactivation of Biofilm Producing Cells: Potential for Treatment of C. albicans Infection in BALB/c Mice
TL;DR: The GNP-PS conjugate based PDT can be employed effectively in treatment of cutaneous C. albicans infections in model animals and exhibits synergism in photodynamic inactivation of C.Albicans.
Journal ArticleDOI
Nanocoatings for Chronic Wound Repair—Modulation of Microbial Colonization and Biofilm Formation
Mara Mădălina Mihai,Mădălina Preda,Iulia Ioana Lungu,Monica Cartelle Gestal,Mircea Ioan Popa,Alina Maria Holban +5 more
TL;DR: This comprehensive review comprises the pathogenesis of chronic wounds, the role of chronic wound colonization and infection in the healing process, the conventional and alternative topical therapeutic approaches designed to combat infection and stimulate healing, as well as revolutionizing therapies such as nanotechnology-based wound healing approaches.
Journal ArticleDOI
Wound biofilms: lessons learned from oral biofilms
TL;DR: Comparisons are made on biofilm detection, biofilm formation, the immune response to biofilms, bacterial interaction, and quorum sensing, and current treatment modalities used by both fields and future therapies are discussed.
Journal ArticleDOI
Modified wound dressing with phyto-nanostructured coating to prevent staphylococcal and pseudomonal biofilm development
Ion Anghel,Alina Maria Holban,Alexandru Mihai Grumezescu,Ecaterina Andronescu,Anton Ficai,Alina Georgiana Anghel,Maria Maganu,Veronica Lazǎr,Mariana Carmen Chifiriuc +8 more
TL;DR: A newly fabricated nanophyto-modified wound dressing with microbicidal and anti-adherence properties is reported, which seems to be a very useful tool for the prevention of wound microbial contamination on viable tissues.
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Bacterial Aggregates Establish at the Edges of Acute Epidermal Wounds.
Lene Bay,Kasper Nørskov Kragh,Steffen Eickhardt,Steen Seier Poulsen,Lise Mette Rahbek Gjerdrum,Khaled Ghathian,Henrik Calum,Magnus S. Ågren,Thomas Bjarnsholt +8 more
TL;DR: Bacterial aggregates were observed at the edges of acute epidermal wounds, indicating initiated establishment of a biofilm.
References
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Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
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TL;DR: It is shown that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis.
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Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Frances J.D. Smith,Alan D. Irvine,Ana Terron-Kwiatkowski,Aileen Sandilands,Linda E. Campbell,Yiwei Zhao,Haihui Liao,Alan Evans,David Goudie,Sue Lewis-Jones,Gehan Arseculeratne,Colin S. Munro,Ann Sergeant,Grainne M. O'Regan,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Richard B. Presland,Philip Fleckman,W.H. Irwin McLean +20 more
TL;DR: It is found that loss or reduction of this major structural protein, filaggrin, leads to varying degrees of impaired keratinization.
Journal ArticleDOI
Epidermal Barrier Dysfunction in Atopic Dermatitis
Michael J. Cork,Simon G. Danby,Yiannis Vasilopoulos,Jonathan Hadgraft,Majella E. Lane,Manar Moustafa,Manar Moustafa,Richard H. Guy,Alice Macgowan,Rachid Tazi-Ahnini,Simon J. Ward +10 more
TL;DR: The strong association between both genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal barrier dysfunction is a primary event in the development of this disease.
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Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
Anaïs Briot,Céline Deraison,Céline Deraison,Matthieu Lacroix,Matthieu Lacroix,Chrystelle Bonnart,Chrystelle Bonnart,Aurélie Robin,Aurélie Robin,Céline Besson,Céline Besson,Pierre Dubus,Alain Hovnanian,Alain Hovnanian +13 more
TL;DR: In this article, the authors showed that the pro-Th2 cytokine thymic stromal lymphopoietin (TSLP), the thymus and activation-regulated chemokine are overexpressed in LEKTI-deficient epidermis.
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Animal models of atopic dermatitis
TL;DR: Since the description of the Nc/Nga mouse as a spontaneously occurring model of AD, a number of other mouse models of AD have been developed, which resulted in a better understanding of the pathogenesis of AD.