Biogenesis of Mitochondria, XVIII. A New Class of Cytoplasmically Determined Antibiotic Resistant Mutants in Saccharomyces cerevisiae
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Cites result from "Biogenesis of Mitochondria, XVIII. ..."
...However, a dominance of the CAPS allele would be in contrast to the available evidence from bacterial systems indicating that the CAPS ribosomes are not "frozen" by CAP on the polysomes and are therefore not expected to block the passage of the resistant ones (18); also, the well-documented isolation of CAPr mutants of Saccharomyces cerevisiae (4, 7) and mammalian cells (44, 48) under selective conditions, which would require the initial expression of single mutant mtDNA molecules mixed with wild-type molecules, argues strongly against a dominance of the CAPS allele....
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Cites background from "Biogenesis of Mitochondria, XVIII. ..."
...The tight association of fungal mitochondrial ribosomes with the inner membrane is known for a long time as the addition of detergent is necessary for their isolation (Bunn et al, 1970; Borst and Grivell, 1971)....
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...…ribosomes remain membrane-associated in the absence of both Mba1 and Oxa1 In contrast to cytosolic ribosomes, mitochondrial ribosomes are tightly associated with membranes and, at least in fungi, can only be released by treatment with detergents (Bunn et al, 1970; Borst and Grivell, 1971)....
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